Mitochondria-derived reactive oxygen species drive GANT61-induced mesothelioma cell apoptosis

Gli transcription factors of the Hedgehog (Hh) pathway have been reported to be drivers of malignant mesothelioma (MMe) cell survival. The Gli inhibitor GANT61 induces apoptosis in various cancer cell models, and has been associated directly with Gli inhibition. However various chemotherapeutics can...

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Detalles Bibliográficos
Autores principales: Lim, Chuan Bian, Prêle, Cecilia M., Baltic, Svetlana, Arthur, Peter G., Creaney, Jenette, Watkins, D. Neil, Thompson, Philip J., Mutsaers, Steven E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4359311/
https://www.ncbi.nlm.nih.gov/pubmed/25544756

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