Cargando…

Identification of human TERT elements necessary for telomerase recruitment to telomeres

Human chromosomes terminate in telomeres, repetitive DNA sequences bound by the shelterin complex. Shelterin protects chromosome ends, prevents recognition by the DNA damage machinery, and recruits telomerase. A patch of amino acids, termed the TEL-patch, on the OB-fold domain of the shelterin compo...

Descripción completa

Detalles Bibliográficos
Autores principales:	Schmidt, Jens C, Dalby, Andrew B, Cech, Thomas R
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2014
Materias:	Biochemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4359370/ https://www.ncbi.nlm.nih.gov/pubmed/25271372 http://dx.doi.org/10.7554/eLife.03563

Ejemplares similares

Dynamics of human telomerase recruitment depend on template-telomere base pairing
por: Schmidt, Jens C., et al.
Publicado: (2018)

Human telomerase: biogenesis, trafficking, recruitment, and activation
por: Schmidt, Jens C., et al.
Publicado: (2015)

The TEL patch of telomere protein TPP1 mediates telomerase recruitment and processivity
por: Nandakumar, Jayakrishnan, et al.
Publicado: (2012)

Telomere Lengths, Pulmonary Fibrosis and Telomerase (TERT) Mutations
por: Diaz de Leon, Alberto, et al.
Publicado: (2010)

Inventory of telomerase components in human cells reveals multiple subpopulations of hTR and hTERT
por: Xi, Linghe, et al.
Publicado: (2014)

Allele‐specific proximal promoter hypomethylation of the telomerase reverse transcriptase gene (TERT) associates with TERT expression in multiple cancers
por: Rowland, Teisha J., et al.
Publicado: (2020)

The β-carboline alkaloid harmine inhibits telomerase activity of MCF-7 cells by down-regulating hTERT mRNA expression accompanied by an accelerated senescent phenotype
por: Zhao, Lei, et al.
Publicado: (2013)

A mechanism for the extension and unfolding of parallel telomeric G-quadruplexes by human telomerase at single-molecule resolution
por: Paudel, Bishnu P, et al.
Publicado: (2020)

Two Pathways Recruit Telomerase to Saccharomyces cerevisiae Telomeres
por: Chan, Angela, et al.
Publicado: (2008)

Effects of hTERT transfection on the telomere and telomerase of Periplaneta americana cells in vitro
por: Ma, Chenjing, et al.
Publicado: (2023)

Research Progress on G-Quadruplexes in Human Telomeres and Human Telomerase Reverse Transcriptase (hTERT) Promoter
por: Gu, Wei, et al.
Publicado: (2022)

The Ku subunit of telomerase binds Sir4 to recruit telomerase to lengthen telomeres in S. cerevisiae
por: Hass, Evan P, et al.
Publicado: (2015)

A novel two-step genome editing strategy with CRISPR-Cas9 provides new insights into telomerase action and TERT gene expression
por: Xi, Linghe, et al.
Publicado: (2015)

The Role of Alternative RNA Splicing in the Regulation of hTERT, Telomerase, and Telomeres: Implications for Cancer Therapeutics
por: Slusher, Aaron L., et al.
Publicado: (2020)

Many disease-associated variants of hTERT retain high telomerase enzymatic activity
por: Zaug, Arthur J., et al.
Publicado: (2013)

The Shelterin TIN2 Subunit Mediates Recruitment of Telomerase to Telomeres
por: Frank, Amanda K., et al.
Publicado: (2015)

Elucidation of the mode of interaction in the UP1–telomerase RNA–telomeric DNA ternary complex which serves to recruit telomerase to telomeric DNA and to enhance the telomerase activity
por: Nagata, Takashi, et al.
Publicado: (2008)

Inhibition of telomerase RNA decay rescues telomerase deficiency caused by dyskerin or PARN defects
por: Shukla, Siddharth, et al.
Publicado: (2016)

Multi-step coordination of telomerase recruitment in fission yeast through two coupled telomere-telomerase interfaces
por: Hu, Xichan, et al.
Publicado: (2016)

Telomerase reverse transcriptase promotes angiogenesis in neonatal rats after hypoxic-ischemic brain damage
por: Li, Jiao, et al.
Publicado: (2022)

BIBR1532 inhibits proliferation and enhances apoptosis in multiple myeloma cells by reducing telomerase activity
por: Zhang, Yuefeng, et al.
Publicado: (2023)

Post-Transcriptional and Post-Translational Modifications in Telomerase Biogenesis and Recruitment to Telomeres
por: Shepelev, Nikita, et al.
Publicado: (2023)

The RNA accordion model for template positioning by telomerase RNA during telomeric DNA synthesis
por: Berman, Andrea J., et al.
Publicado: (2011)

A new telomerase RNA element that is critical for telomere elongation
por: Laterreur, Nancy, et al.
Publicado: (2013)

Regulation of the Human Telomerase Gene TERT by Telomere Position Effect—Over Long Distances (TPE-OLD): Implications for Aging and Cancer
por: Kim, Wanil, et al.
Publicado: (2016)

Telomeres and telomerase in oncogenesis
por: Trybek, Tomasz, et al.
Publicado: (2020)

The yeast telomerase module for telomere recruitment requires a specific RNA architecture
por: Laterreur, Nancy, et al.
Publicado: (2018)

Distinct functions of POT1 proteins contribute to the regulation of telomerase recruitment to telomeres
por: Gu, Peili, et al.
Publicado: (2021)

Inhibition of yeast telomerase action by the telomeric ssDNA-binding protein, Cdc13p
por: Zappulla, David C., et al.
Publicado: (2009)

The yeast telomerase RNA, TLC1, participates in two distinct modes of TLC1-TLC1 association processes in vivo
por: Matsuguchi, Tet, et al.
Publicado: (2016)

Structural characterization of ribosome recruitment and translocation by type IV IRES
por: Murray, Jason, et al.
Publicado: (2016)

TERT Promoter Mutations and Telomerase in Melanoma
por: Guo, Yuchen, et al.
Publicado: (2022)

Identification of telomerase RNAs in species of the Yarrowia clade provides insights into the co-evolution of telomerase, telomeric repeats and telomere-binding proteins
por: Červenák, Filip, et al.
Publicado: (2019)

Artemisinin mimics calorie restriction to trigger mitochondrial biogenesis and compromise telomere shortening in mice
por: Wang, Da-Ting, et al.
Publicado: (2015)

The leukocyte telomere length, single nucleotide polymorphisms near TERC gene and risk of COPD
por: Tacheva, Tanya, et al.
Publicado: (2021)

Mechanisms of nucleotide selection by telomerase
por: Schaich, Matthew A, et al.
Publicado: (2020)

Involvement of SRSF11 in cell cycle-specific recruitment of telomerase to telomeres at nuclear speckles
por: Lee, Ji Hoon, et al.
Publicado: (2015)

CDK-regulated dimerization of M18BP1 on a Mis18 hexamer is necessary for CENP-A loading
por: Pan, Dongqing, et al.
Publicado: (2017)

Relative telomere length and oxidative DNA damage in hypertrophic ligamentum flavum of lumbar spinal stenosis
por: Dechsupa, Sinsuda, et al.
Publicado: (2018)

Telomere and telomerase in stem cells
por: Hiyama, E, et al.
Publicado: (2007)

Cannot write session to /tmp/vufind_sessions/sess_6lhdbt97pmef4tadknbjg7nspc