Active RNAP pre-initiation sites are highly mutated by cytidine deaminases in yeast, with AID targeting small RNA genes

Cytidine deaminases are single stranded DNA mutators diversifying antibodies and restricting viral infection. Improper access to the genome leads to translocations and mutations in B cells and contributes to the mutation landscape in cancer, such as kataegis. It remains unclear how deaminases access...

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Detalles Bibliográficos
Autores principales: Taylor, Benjamin JM, Wu, Yee Ling, Rada, Cristina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2014
Materias:
Genes and Chromosomes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4359381/
https://www.ncbi.nlm.nih.gov/pubmed/25237741
http://dx.doi.org/10.7554/eLife.03553

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4359381/
https://www.ncbi.nlm.nih.gov/pubmed/25237741
http://dx.doi.org/10.7554/eLife.03553

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