Effect of thymic stimulation of CD4+ T cell expansion on disease onset and progression in mutant SOD1 mice

BACKGROUND: The peripheral immune system is implicated in modulating microglial activation, neurodegeneration and disease progression in amyotrophic lateral sclerosis (ALS). Specifically, there is reduced thymic function and regulatory T cell (Treg) number in ALS patients and mutant superoxide dismu...

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Detalles Bibliográficos
Autores principales: Sheean, Rebecca K, Weston, Richard H, Perera, Nirma D, D’Amico, Angela, Nutt, Stephen L, Turner, Bradley J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4359394/
https://www.ncbi.nlm.nih.gov/pubmed/25889790
http://dx.doi.org/10.1186/s12974-015-0254-3

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