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PhyloWGS: Reconstructing subclonal composition and evolution from whole-genome sequencing of tumors

Tumors often contain multiple subpopulations of cancerous cells defined by distinct somatic mutations. We describe a new method, PhyloWGS, which can be applied to whole-genome sequencing data from one or more tumor samples to reconstruct complete genotypes of these subpopulations based on variant al...

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Detalles Bibliográficos
Autores principales:	Deshwar, Amit G, Vembu, Shankar, Yung, Christina K, Jang, Gun Ho, Stein, Lincoln, Morris, Quaid
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Method
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4359439/ https://www.ncbi.nlm.nih.gov/pubmed/25786235 http://dx.doi.org/10.1186/s13059-015-0602-8

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