LAMP-2 deficiency leads to hippocampal dysfunction but normal clearance of neuronal substrates of chaperone-mediated autophagy in a mouse model for Danon disease

The Lysosomal Associated Membrane Protein type-2 (LAMP-2) is an abundant lysosomal membrane protein with an important role in immunity, macroautophagy (MA) and chaperone-mediated autophagy (CMA). Mutations within the Lamp2 gene cause Danon disease, an X-linked lysosomal storage disorder characterize...

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Detalles Bibliográficos
Autores principales: Rothaug, Michelle, Stroobants, Stijn, Schweizer, Michaela, Peters, Judith, Zunke, Friederike, Allerding, Mirka, D’Hooge, Rudi, Saftig, Paul, Blanz, Judith
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4359523/
https://www.ncbi.nlm.nih.gov/pubmed/25637286
http://dx.doi.org/10.1186/s40478-014-0182-y

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