Effective immuno-targeting of the IDH1 mutation R132H in a murine model of intracranial glioma

The R132H mutation of cytosolic isocitrate dehydrogenase (IDH1) is present in the majority of low grade gliomas. Immunotherapy in these tumors has an interesting, still unexploited, therapeutic potential, as they are less immunosuppressive than glioblastomas. Using site-directed mutagenesis we intro...

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Detalles Bibliográficos
Autores principales: Pellegatta, Serena, Valletta, Lorella, Corbetta, Cristina, Patanè, Monica, Zucca, Ileana, Riccardi Sirtori, Federico, Bruzzone, Maria Grazia, Fogliatto, Gianpaolo, Isacchi, Antonella, Pollo, Bianca, Finocchiaro, Gaetano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4359524/
https://www.ncbi.nlm.nih.gov/pubmed/25849072
http://dx.doi.org/10.1186/s40478-014-0180-0

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