Loss of angiotensin II receptor expression in dopamine neurons in Parkinson’s disease correlates with pathological progression and is accompanied by increases in Nox4- and 8-OH guanosine-related nucleic acid oxidation and caspase-3 activation

BACKGROUND: In rodent models of Parkinson’s disease (PD), dopamine neuron loss is accompanied by increased expression of angiotensin II (AngII), its type 1 receptor (AT1), and NADPH oxidase (Nox) in the nigral dopamine neurons and microglia. AT1 blockers (ARBs) stymie such oxidative damage and neuro...

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Detalles Bibliográficos
Autores principales: Zawada, W Michael, Mrak, Robert E, Biedermann, JoAnn, Palmer, Quinton D, Gentleman, Stephen M, Aboud, Orwa, Griffin, W Sue T
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4359535/
https://www.ncbi.nlm.nih.gov/pubmed/25645462
http://dx.doi.org/10.1186/s40478-015-0189-z

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