Lack of Association between miRNA-146a rs2910164 and miRNA-499 rs3746444 Gene Polymorphisms and Susceptibility to Pulmonary Tuberculosis

Single-nucleotide polymorphisms (SNPs) in miRNAsmay alter its expression levels or processing and contribute to susceptibility to a wide range of diseases. Our study aimed to evaluate the possible association between miRNA-146a rs2910164 and miRNA-499 rs3746444 polymorphisms and susceptibility to pu...

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Autores principales: Naderi, Mohammad, Hashemi, Mohammad, Khorgami, Parisa, Koshki, Maliheh, Ebrahimi, Mahboubeh, Amininia, Shadi, Sharifi-Mood, Batool, Taheri, Mohsen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Babol University of Medical Sciences 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4359704/
https://www.ncbi.nlm.nih.gov/pubmed/25815281
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author Naderi, Mohammad
Hashemi, Mohammad
Khorgami, Parisa
Koshki, Maliheh
Ebrahimi, Mahboubeh
Amininia, Shadi
Sharifi-Mood, Batool
Taheri, Mohsen
author_facet Naderi, Mohammad
Hashemi, Mohammad
Khorgami, Parisa
Koshki, Maliheh
Ebrahimi, Mahboubeh
Amininia, Shadi
Sharifi-Mood, Batool
Taheri, Mohsen
author_sort Naderi, Mohammad
collection PubMed
description Single-nucleotide polymorphisms (SNPs) in miRNAsmay alter its expression levels or processing and contribute to susceptibility to a wide range of diseases. Our study aimed to evaluate the possible association between miRNA-146a rs2910164 and miRNA-499 rs3746444 polymorphisms and susceptibility to pulmonary tuberculosis (PTB) in a sample of Iranian population. This case- control study was performed on 202 PTB patients and 204 healthy individuals. Genotyping was performed using tetra amplification refractory mutation system-polymerase chain reaction (T-ARMS-PCR). The results indicated that neither miRNA-499 rs3746444 nor miRNA-146a rs2910164 are associated with the risk of PTB in a sample of Iranian population. Larger studies with different ethnicities are required to validate our findings.
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spelling pubmed-43597042015-03-26 Lack of Association between miRNA-146a rs2910164 and miRNA-499 rs3746444 Gene Polymorphisms and Susceptibility to Pulmonary Tuberculosis Naderi, Mohammad Hashemi, Mohammad Khorgami, Parisa Koshki, Maliheh Ebrahimi, Mahboubeh Amininia, Shadi Sharifi-Mood, Batool Taheri, Mohsen Int J Mol Cell Med Original Article Single-nucleotide polymorphisms (SNPs) in miRNAsmay alter its expression levels or processing and contribute to susceptibility to a wide range of diseases. Our study aimed to evaluate the possible association between miRNA-146a rs2910164 and miRNA-499 rs3746444 polymorphisms and susceptibility to pulmonary tuberculosis (PTB) in a sample of Iranian population. This case- control study was performed on 202 PTB patients and 204 healthy individuals. Genotyping was performed using tetra amplification refractory mutation system-polymerase chain reaction (T-ARMS-PCR). The results indicated that neither miRNA-499 rs3746444 nor miRNA-146a rs2910164 are associated with the risk of PTB in a sample of Iranian population. Larger studies with different ethnicities are required to validate our findings. Babol University of Medical Sciences 2015 /pmc/articles/PMC4359704/ /pubmed/25815281 Text en This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Naderi, Mohammad
Hashemi, Mohammad
Khorgami, Parisa
Koshki, Maliheh
Ebrahimi, Mahboubeh
Amininia, Shadi
Sharifi-Mood, Batool
Taheri, Mohsen
Lack of Association between miRNA-146a rs2910164 and miRNA-499 rs3746444 Gene Polymorphisms and Susceptibility to Pulmonary Tuberculosis
title Lack of Association between miRNA-146a rs2910164 and miRNA-499 rs3746444 Gene Polymorphisms and Susceptibility to Pulmonary Tuberculosis
title_full Lack of Association between miRNA-146a rs2910164 and miRNA-499 rs3746444 Gene Polymorphisms and Susceptibility to Pulmonary Tuberculosis
title_fullStr Lack of Association between miRNA-146a rs2910164 and miRNA-499 rs3746444 Gene Polymorphisms and Susceptibility to Pulmonary Tuberculosis
title_full_unstemmed Lack of Association between miRNA-146a rs2910164 and miRNA-499 rs3746444 Gene Polymorphisms and Susceptibility to Pulmonary Tuberculosis
title_short Lack of Association between miRNA-146a rs2910164 and miRNA-499 rs3746444 Gene Polymorphisms and Susceptibility to Pulmonary Tuberculosis
title_sort lack of association between mirna-146a rs2910164 and mirna-499 rs3746444 gene polymorphisms and susceptibility to pulmonary tuberculosis
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4359704/
https://www.ncbi.nlm.nih.gov/pubmed/25815281
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