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Protective Actions of 17β-Estradiol and Progesterone on Oxidative Neuronal Injury Induced by Organometallic Compounds
Steroid hormones synthesized in and secreted from peripheral endocrine glands pass through the blood-brain barrier and play a role in the central nervous system. In addition, the brain possesses an inherent endocrine system and synthesizes steroid hormones known as neurosteroids. Increasing evidence...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4359856/ https://www.ncbi.nlm.nih.gov/pubmed/25815107 http://dx.doi.org/10.1155/2015/343706 |
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author | Ishihara, Yasuhiro Takemoto, Takuya Ishida, Atsuhiko Yamazaki, Takeshi |
author_facet | Ishihara, Yasuhiro Takemoto, Takuya Ishida, Atsuhiko Yamazaki, Takeshi |
author_sort | Ishihara, Yasuhiro |
collection | PubMed |
description | Steroid hormones synthesized in and secreted from peripheral endocrine glands pass through the blood-brain barrier and play a role in the central nervous system. In addition, the brain possesses an inherent endocrine system and synthesizes steroid hormones known as neurosteroids. Increasing evidence shows that neuroactive steroids protect the central nervous system from various harmful stimuli. Reports show that the neuroprotective actions of steroid hormones attenuate oxidative stress. In this review, we summarize the antioxidative effects of neuroactive steroids, especially 17β-estradiol and progesterone, on neuronal injury in the central nervous system under various pathological conditions, and then describe our recent findings concerning the neuroprotective actions of 17β-estradiol and progesterone on oxidative neuronal injury induced by organometallic compounds, tributyltin, and methylmercury. |
format | Online Article Text |
id | pubmed-4359856 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-43598562015-03-26 Protective Actions of 17β-Estradiol and Progesterone on Oxidative Neuronal Injury Induced by Organometallic Compounds Ishihara, Yasuhiro Takemoto, Takuya Ishida, Atsuhiko Yamazaki, Takeshi Oxid Med Cell Longev Review Article Steroid hormones synthesized in and secreted from peripheral endocrine glands pass through the blood-brain barrier and play a role in the central nervous system. In addition, the brain possesses an inherent endocrine system and synthesizes steroid hormones known as neurosteroids. Increasing evidence shows that neuroactive steroids protect the central nervous system from various harmful stimuli. Reports show that the neuroprotective actions of steroid hormones attenuate oxidative stress. In this review, we summarize the antioxidative effects of neuroactive steroids, especially 17β-estradiol and progesterone, on neuronal injury in the central nervous system under various pathological conditions, and then describe our recent findings concerning the neuroprotective actions of 17β-estradiol and progesterone on oxidative neuronal injury induced by organometallic compounds, tributyltin, and methylmercury. Hindawi Publishing Corporation 2015 2015-03-01 /pmc/articles/PMC4359856/ /pubmed/25815107 http://dx.doi.org/10.1155/2015/343706 Text en Copyright © 2015 Yasuhiro Ishihara et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Ishihara, Yasuhiro Takemoto, Takuya Ishida, Atsuhiko Yamazaki, Takeshi Protective Actions of 17β-Estradiol and Progesterone on Oxidative Neuronal Injury Induced by Organometallic Compounds |
title | Protective Actions of 17β-Estradiol and Progesterone on Oxidative Neuronal Injury Induced by Organometallic Compounds |
title_full | Protective Actions of 17β-Estradiol and Progesterone on Oxidative Neuronal Injury Induced by Organometallic Compounds |
title_fullStr | Protective Actions of 17β-Estradiol and Progesterone on Oxidative Neuronal Injury Induced by Organometallic Compounds |
title_full_unstemmed | Protective Actions of 17β-Estradiol and Progesterone on Oxidative Neuronal Injury Induced by Organometallic Compounds |
title_short | Protective Actions of 17β-Estradiol and Progesterone on Oxidative Neuronal Injury Induced by Organometallic Compounds |
title_sort | protective actions of 17β-estradiol and progesterone on oxidative neuronal injury induced by organometallic compounds |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4359856/ https://www.ncbi.nlm.nih.gov/pubmed/25815107 http://dx.doi.org/10.1155/2015/343706 |
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