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3-Nitrotyrosine Modified Proteins in Atherosclerosis

Cardiovascular disease is the leading cause of premature death worldwide, and atherosclerosis is the main contributor. Lipid-laden macrophages, known as foam cells, accumulate in the subendothelial space of the lesion area and contribute to consolidate a chronic inflammatory environment where oxygen...

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Detalles Bibliográficos
Autor principal: Thomson, Leonor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4359869/
https://www.ncbi.nlm.nih.gov/pubmed/25814781
http://dx.doi.org/10.1155/2015/708282
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author Thomson, Leonor
author_facet Thomson, Leonor
author_sort Thomson, Leonor
collection PubMed
description Cardiovascular disease is the leading cause of premature death worldwide, and atherosclerosis is the main contributor. Lipid-laden macrophages, known as foam cells, accumulate in the subendothelial space of the lesion area and contribute to consolidate a chronic inflammatory environment where oxygen and nitrogen derived oxidants are released. Oxidatively modified lipids and proteins are present both in plasma as well as atherosclerotic lesions. A relevant oxidative posttranslational protein modification is the addition of a nitro group to the hydroxyphenyl ring of tyrosine residues, mediated by nitric oxide derived oxidants. Nitrotyrosine modified proteins were found in the lesion and also in plasma from atherosclerotic patients. Despite the fact of the low yield of nitration, immunogenic, proatherogenic, and prothrombotic properties acquired by 3-nitrotyrosine modified proteins are in agreement with epidemiological studies showing a significant correlation between the level of nitration found in plasma proteins and the prevalence of cardiovascular disease, supporting the usefulness of this biomarker to predict the outcome and to take appropriate therapeutic decisions in atherosclerotic disease.
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spelling pubmed-43598692015-03-26 3-Nitrotyrosine Modified Proteins in Atherosclerosis Thomson, Leonor Dis Markers Review Article Cardiovascular disease is the leading cause of premature death worldwide, and atherosclerosis is the main contributor. Lipid-laden macrophages, known as foam cells, accumulate in the subendothelial space of the lesion area and contribute to consolidate a chronic inflammatory environment where oxygen and nitrogen derived oxidants are released. Oxidatively modified lipids and proteins are present both in plasma as well as atherosclerotic lesions. A relevant oxidative posttranslational protein modification is the addition of a nitro group to the hydroxyphenyl ring of tyrosine residues, mediated by nitric oxide derived oxidants. Nitrotyrosine modified proteins were found in the lesion and also in plasma from atherosclerotic patients. Despite the fact of the low yield of nitration, immunogenic, proatherogenic, and prothrombotic properties acquired by 3-nitrotyrosine modified proteins are in agreement with epidemiological studies showing a significant correlation between the level of nitration found in plasma proteins and the prevalence of cardiovascular disease, supporting the usefulness of this biomarker to predict the outcome and to take appropriate therapeutic decisions in atherosclerotic disease. Hindawi Publishing Corporation 2015 2015-03-01 /pmc/articles/PMC4359869/ /pubmed/25814781 http://dx.doi.org/10.1155/2015/708282 Text en Copyright © 2015 Leonor Thomson. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Thomson, Leonor
3-Nitrotyrosine Modified Proteins in Atherosclerosis
title 3-Nitrotyrosine Modified Proteins in Atherosclerosis
title_full 3-Nitrotyrosine Modified Proteins in Atherosclerosis
title_fullStr 3-Nitrotyrosine Modified Proteins in Atherosclerosis
title_full_unstemmed 3-Nitrotyrosine Modified Proteins in Atherosclerosis
title_short 3-Nitrotyrosine Modified Proteins in Atherosclerosis
title_sort 3-nitrotyrosine modified proteins in atherosclerosis
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4359869/
https://www.ncbi.nlm.nih.gov/pubmed/25814781
http://dx.doi.org/10.1155/2015/708282
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