Krüppel-like factor 4 induces apoptosis and inhibits tumorigenic progression in SK-BR-3 breast cancer cells

Krüppel-like factor 4 (KLF4) functions as either a tumor suppressor or an oncogene in different tissues by regulating the expression of various genes. The aim of this study was to reveal the functions of KLF4 in regulating breast cancer apoptosis, proliferation, and tumorigenic progression. KLF4 exp...

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Autores principales: Wang, Bing, Zhao, Ming-zhi, Cui, Nai-peng, Lin, Dan-dan, Zhang, An-yi, Qin, Yan, Liu, Cai-yun, Yan, Wei-tao, Shi, Jian-hong, Chen, Bao-ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4359971/
https://www.ncbi.nlm.nih.gov/pubmed/25834779
http://dx.doi.org/10.1016/j.fob.2015.02.003
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author Wang, Bing
Zhao, Ming-zhi
Cui, Nai-peng
Lin, Dan-dan
Zhang, An-yi
Qin, Yan
Liu, Cai-yun
Yan, Wei-tao
Shi, Jian-hong
Chen, Bao-ping
author_facet Wang, Bing
Zhao, Ming-zhi
Cui, Nai-peng
Lin, Dan-dan
Zhang, An-yi
Qin, Yan
Liu, Cai-yun
Yan, Wei-tao
Shi, Jian-hong
Chen, Bao-ping
author_sort Wang, Bing
collection PubMed
description Krüppel-like factor 4 (KLF4) functions as either a tumor suppressor or an oncogene in different tissues by regulating the expression of various genes. The aim of this study was to reveal the functions of KLF4 in regulating breast cancer apoptosis, proliferation, and tumorigenic progression. KLF4 expression levels in breast cancer tissues and breast cancer cell lines were found to be much lower than those in nontumorous tissues and a nontransformed mammary epithelial cell line. KLF4 was upregulated in the tumor necrosis factor-α–induced SK-BR-3 breast cancer cell apoptotic process. Overexpression of KLF4 promoted SK-BR-3 breast cancer cell apoptosis and suppressed SK-BR-3 cell tumorigenicity in vivo.
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spelling pubmed-43599712015-04-01 Krüppel-like factor 4 induces apoptosis and inhibits tumorigenic progression in SK-BR-3 breast cancer cells Wang, Bing Zhao, Ming-zhi Cui, Nai-peng Lin, Dan-dan Zhang, An-yi Qin, Yan Liu, Cai-yun Yan, Wei-tao Shi, Jian-hong Chen, Bao-ping FEBS Open Bio Article Krüppel-like factor 4 (KLF4) functions as either a tumor suppressor or an oncogene in different tissues by regulating the expression of various genes. The aim of this study was to reveal the functions of KLF4 in regulating breast cancer apoptosis, proliferation, and tumorigenic progression. KLF4 expression levels in breast cancer tissues and breast cancer cell lines were found to be much lower than those in nontumorous tissues and a nontransformed mammary epithelial cell line. KLF4 was upregulated in the tumor necrosis factor-α–induced SK-BR-3 breast cancer cell apoptotic process. Overexpression of KLF4 promoted SK-BR-3 breast cancer cell apoptosis and suppressed SK-BR-3 cell tumorigenicity in vivo. Elsevier 2015-03-02 /pmc/articles/PMC4359971/ /pubmed/25834779 http://dx.doi.org/10.1016/j.fob.2015.02.003 Text en © 2015 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Wang, Bing
Zhao, Ming-zhi
Cui, Nai-peng
Lin, Dan-dan
Zhang, An-yi
Qin, Yan
Liu, Cai-yun
Yan, Wei-tao
Shi, Jian-hong
Chen, Bao-ping
Krüppel-like factor 4 induces apoptosis and inhibits tumorigenic progression in SK-BR-3 breast cancer cells
title Krüppel-like factor 4 induces apoptosis and inhibits tumorigenic progression in SK-BR-3 breast cancer cells
title_full Krüppel-like factor 4 induces apoptosis and inhibits tumorigenic progression in SK-BR-3 breast cancer cells
title_fullStr Krüppel-like factor 4 induces apoptosis and inhibits tumorigenic progression in SK-BR-3 breast cancer cells
title_full_unstemmed Krüppel-like factor 4 induces apoptosis and inhibits tumorigenic progression in SK-BR-3 breast cancer cells
title_short Krüppel-like factor 4 induces apoptosis and inhibits tumorigenic progression in SK-BR-3 breast cancer cells
title_sort krüppel-like factor 4 induces apoptosis and inhibits tumorigenic progression in sk-br-3 breast cancer cells
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4359971/
https://www.ncbi.nlm.nih.gov/pubmed/25834779
http://dx.doi.org/10.1016/j.fob.2015.02.003
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