Presence of rd8 mutation does not alter the ocular phenotype of late-onset retinal degeneration mouse model

PURPOSE: A spontaneous frameshift mutation, c.3481delC, in the Crb1 gene is the underlying cause of dysplasia and retinal degeneration in rd8 mice. The rd8 mutation is found in C57BL/6N but not in C57BL/6J mouse sub-strains. The development of ocular pathology in single knockout Ccl2(−/−), Cx3cr1(−/...

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Autores principales: Sahu, Bhubanananda, Chavali, Venkata R.M., Alapati, Akhila, Suk, John, Bartsch, Dirk-Uwe, Jablonski, Monica M., Ayyagari, Radha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Vision 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4360165/
https://www.ncbi.nlm.nih.gov/pubmed/25814825

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