PAINS in the Assay: Chemical Mechanisms of Assay Interference and Promiscuous Enzymatic Inhibition Observed during a Sulfhydryl-Scavenging HTS

[Image: see text] Significant resources in early drug discovery are spent unknowingly pursuing artifacts and promiscuous bioactive compounds, while understanding the chemical basis for these adverse behaviors often goes unexplored in pursuit of lead compounds. Nearly all the hits from our recent sul...

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Detalles Bibliográficos
Autores principales: Dahlin, Jayme L., Nissink, J. Willem M., Strasser, Jessica M., Francis, Subhashree, Higgins, LeeAnn, Zhou, Hui, Zhang, Zhiguo, Walters, Michael A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2015
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4360378/
https://www.ncbi.nlm.nih.gov/pubmed/25634295
http://dx.doi.org/10.1021/jm5019093

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