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The significance of serum uric acid level in humans with acute paraquat poisoning

Hyperuricemia is a strong and independent predictor of all-cause mortality in cardiovascular disease and has been found to play a role in diseases exacerbated by oxidative stress and inflammation. This study aimed to evaluate whether serum uric acid (UA) level is an indicator of outcome in patients...

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Autores principales: Zhang, JuanWen, Zhao, Ying, Bai, YunJuan, Lv, GuoCai, Wu, JianPing, Chen, Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4360628/
https://www.ncbi.nlm.nih.gov/pubmed/25772718
http://dx.doi.org/10.1038/srep09168
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author Zhang, JuanWen
Zhao, Ying
Bai, YunJuan
Lv, GuoCai
Wu, JianPing
Chen, Yu
author_facet Zhang, JuanWen
Zhao, Ying
Bai, YunJuan
Lv, GuoCai
Wu, JianPing
Chen, Yu
author_sort Zhang, JuanWen
collection PubMed
description Hyperuricemia is a strong and independent predictor of all-cause mortality in cardiovascular disease and has been found to play a role in diseases exacerbated by oxidative stress and inflammation. This study aimed to evaluate whether serum uric acid (UA) level is an indicator of outcome in patients with acute paraquat poisoning. A total of 205 subjects who had attempted suicide by oral ingestion of paraquat were admitted to the emergency room between January 2009 and June 2014. Initial serum UA level and other laboratory parameters were measured. A total of 66 patients died during the 30 days after admission, corresponding to a 32.2% cumulative incidence of mortality. UA levels were higher in non-survivors than survivors (P < 0.001) and 30-day mortality increased with increasing baseline serum UA level (P < 0.001). In a prediction analysis for 30-day mortality, the serum UA level had a cut-off concentration of 284 µmol/L in female patients and 352 µmol/L in male patients. Multivariate Cox proportional hazards regression analyses showed that white blood cell counts and UA were independent prognostic factors. In conclusion, we showed that serum UA may be an independent predictor of 30-day mortality in patients with paraquat poisoning.
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spelling pubmed-43606282015-03-19 The significance of serum uric acid level in humans with acute paraquat poisoning Zhang, JuanWen Zhao, Ying Bai, YunJuan Lv, GuoCai Wu, JianPing Chen, Yu Sci Rep Article Hyperuricemia is a strong and independent predictor of all-cause mortality in cardiovascular disease and has been found to play a role in diseases exacerbated by oxidative stress and inflammation. This study aimed to evaluate whether serum uric acid (UA) level is an indicator of outcome in patients with acute paraquat poisoning. A total of 205 subjects who had attempted suicide by oral ingestion of paraquat were admitted to the emergency room between January 2009 and June 2014. Initial serum UA level and other laboratory parameters were measured. A total of 66 patients died during the 30 days after admission, corresponding to a 32.2% cumulative incidence of mortality. UA levels were higher in non-survivors than survivors (P < 0.001) and 30-day mortality increased with increasing baseline serum UA level (P < 0.001). In a prediction analysis for 30-day mortality, the serum UA level had a cut-off concentration of 284 µmol/L in female patients and 352 µmol/L in male patients. Multivariate Cox proportional hazards regression analyses showed that white blood cell counts and UA were independent prognostic factors. In conclusion, we showed that serum UA may be an independent predictor of 30-day mortality in patients with paraquat poisoning. Nature Publishing Group 2015-03-16 /pmc/articles/PMC4360628/ /pubmed/25772718 http://dx.doi.org/10.1038/srep09168 Text en Copyright © 2015, Macmillan Publishers Limited. All rights reserved http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder in order to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Zhang, JuanWen
Zhao, Ying
Bai, YunJuan
Lv, GuoCai
Wu, JianPing
Chen, Yu
The significance of serum uric acid level in humans with acute paraquat poisoning
title The significance of serum uric acid level in humans with acute paraquat poisoning
title_full The significance of serum uric acid level in humans with acute paraquat poisoning
title_fullStr The significance of serum uric acid level in humans with acute paraquat poisoning
title_full_unstemmed The significance of serum uric acid level in humans with acute paraquat poisoning
title_short The significance of serum uric acid level in humans with acute paraquat poisoning
title_sort significance of serum uric acid level in humans with acute paraquat poisoning
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4360628/
https://www.ncbi.nlm.nih.gov/pubmed/25772718
http://dx.doi.org/10.1038/srep09168
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