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Exome sequencing of case-unaffected-parents trios reveals recessive and de novo genetic variants in sporadic ALS
The contribution of genetic variants to sporadic amyotrophic lateral sclerosis (ALS) remains largely unknown. Either recessive or de novo variants could result in an apparently sporadic occurrence of ALS. In an attempt to find such variants we sequenced the exomes of 44 ALS-unaffected-parents trios....
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4360641/ https://www.ncbi.nlm.nih.gov/pubmed/25773295 http://dx.doi.org/10.1038/srep09124 |