Cargando…
Drosophila melanogaster Hsp22: a mitochondrial small heat shock protein influencing the aging process
Mitochondria are involved in many key cellular processes and therefore need to rely on good protein quality control (PQC). Three types of mechanisms are in place to insure mitochondrial protein integrity: reactive oxygen species scavenging by anti-oxidant enzymes, protein folding/degradation by mole...
Autores principales: | , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4360758/ https://www.ncbi.nlm.nih.gov/pubmed/25852752 http://dx.doi.org/10.3389/fgene.2015.00103 |
_version_ | 1782361579952537600 |
---|---|
author | Morrow, Geneviève Tanguay, Robert M. |
author_facet | Morrow, Geneviève Tanguay, Robert M. |
author_sort | Morrow, Geneviève |
collection | PubMed |
description | Mitochondria are involved in many key cellular processes and therefore need to rely on good protein quality control (PQC). Three types of mechanisms are in place to insure mitochondrial protein integrity: reactive oxygen species scavenging by anti-oxidant enzymes, protein folding/degradation by molecular chaperones and proteases and clearance of defective mitochondria by mitophagy. Drosophila melanogaster Hsp22 is part of the molecular chaperone axis of the PQC and is characterized by its intra-mitochondrial localization and preferential expression during aging. As a stress biomarker, the level of its expression during aging has been shown to partially predict the remaining lifespan of flies. Since over-expression of this small heat shock protein increases lifespan and resistance to stress, Hsp22 most likely has a positive effect on mitochondrial integrity. Accordingly, Hsp22 has recently been implicated in the mitochondrial unfolding protein response of flies. This review will summarize the key findings on D. melanogaster Hsp22 and emphasis on its links with the aging process. |
format | Online Article Text |
id | pubmed-4360758 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-43607582015-04-07 Drosophila melanogaster Hsp22: a mitochondrial small heat shock protein influencing the aging process Morrow, Geneviève Tanguay, Robert M. Front Genet Genetics Mitochondria are involved in many key cellular processes and therefore need to rely on good protein quality control (PQC). Three types of mechanisms are in place to insure mitochondrial protein integrity: reactive oxygen species scavenging by anti-oxidant enzymes, protein folding/degradation by molecular chaperones and proteases and clearance of defective mitochondria by mitophagy. Drosophila melanogaster Hsp22 is part of the molecular chaperone axis of the PQC and is characterized by its intra-mitochondrial localization and preferential expression during aging. As a stress biomarker, the level of its expression during aging has been shown to partially predict the remaining lifespan of flies. Since over-expression of this small heat shock protein increases lifespan and resistance to stress, Hsp22 most likely has a positive effect on mitochondrial integrity. Accordingly, Hsp22 has recently been implicated in the mitochondrial unfolding protein response of flies. This review will summarize the key findings on D. melanogaster Hsp22 and emphasis on its links with the aging process. Frontiers Media S.A. 2015-03-16 /pmc/articles/PMC4360758/ /pubmed/25852752 http://dx.doi.org/10.3389/fgene.2015.00103 Text en Copyright © 2015 Morrow and Tanguay. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Genetics Morrow, Geneviève Tanguay, Robert M. Drosophila melanogaster Hsp22: a mitochondrial small heat shock protein influencing the aging process |
title | Drosophila melanogaster Hsp22: a mitochondrial small heat shock protein influencing the aging process |
title_full | Drosophila melanogaster Hsp22: a mitochondrial small heat shock protein influencing the aging process |
title_fullStr | Drosophila melanogaster Hsp22: a mitochondrial small heat shock protein influencing the aging process |
title_full_unstemmed | Drosophila melanogaster Hsp22: a mitochondrial small heat shock protein influencing the aging process |
title_short | Drosophila melanogaster Hsp22: a mitochondrial small heat shock protein influencing the aging process |
title_sort | drosophila melanogaster hsp22: a mitochondrial small heat shock protein influencing the aging process |
topic | Genetics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4360758/ https://www.ncbi.nlm.nih.gov/pubmed/25852752 http://dx.doi.org/10.3389/fgene.2015.00103 |
work_keys_str_mv | AT morrowgenevieve drosophilamelanogasterhsp22amitochondrialsmallheatshockproteininfluencingtheagingprocess AT tanguayrobertm drosophilamelanogasterhsp22amitochondrialsmallheatshockproteininfluencingtheagingprocess |