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Impaired emotional autobiographical memory associated with right amygdalar-hippocampal atrophy in Alzheimer’s disease patients

We studied the influence of emotions on autobiographical memory (AbM) in patients with Alzheimer’s disease (AD), characteristically triggering atrophy in the hippocampus and the amygdala, two crucial structures sustaining memory and emotional processing. Our first aim was to analyze the influence of...

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Autores principales: Philippi, Nathalie, Botzung, Anne, Noblet, Vincent, Rousseau, François, Després, Olivier, Cretin, Benjamin, Kremer, Stéphane, Blanc, Frédéric, Manning, Liliann
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4360763/
https://www.ncbi.nlm.nih.gov/pubmed/25852541
http://dx.doi.org/10.3389/fnagi.2015.00021
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author Philippi, Nathalie
Botzung, Anne
Noblet, Vincent
Rousseau, François
Després, Olivier
Cretin, Benjamin
Kremer, Stéphane
Blanc, Frédéric
Manning, Liliann
author_facet Philippi, Nathalie
Botzung, Anne
Noblet, Vincent
Rousseau, François
Després, Olivier
Cretin, Benjamin
Kremer, Stéphane
Blanc, Frédéric
Manning, Liliann
author_sort Philippi, Nathalie
collection PubMed
description We studied the influence of emotions on autobiographical memory (AbM) in patients with Alzheimer’s disease (AD), characteristically triggering atrophy in the hippocampus and the amygdala, two crucial structures sustaining memory and emotional processing. Our first aim was to analyze the influence of emotion on AbM in AD patients, on both the proportion and the specificity of emotional memories. Additionally, we sought to determine the relationship of emotional AbM to amygdalar-hippocampal volumes. Eighteen prodromal to mild AD patients and 18 age-matched healthy controls were included. We obtained 30 autobiographical memories per participant using the modified Crovitz test (MCT). Analyses were performed on global scores, rates and specificity scores of the emotional vs. neutral categories of memories. Amygdalar-hippocampal volumes were extracted from 3D T1-weighted MRI scans and tested for correlations with behavioral data. Overall, AD patients displayed a deficit in emotional AbMs as they elicited less emotional memories than the controls, however, the specificity of those memories was preserved. The deficit likely implied retrieval or storage as it was extended in time and without reminiscence bump effect. Global scores and rates of emotional memories, but not the specificity scores, were correlated to right amygdalar and hippocampal volumes, indicating that atrophy in these structures has a central role in the deficit observed. Conversely, emotional memories were more specific than neutral memories in both groups, reflecting an enhancement effect of emotion that could be supported by other brain regions that are spared during the early stages of the disease.
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spelling pubmed-43607632015-04-07 Impaired emotional autobiographical memory associated with right amygdalar-hippocampal atrophy in Alzheimer’s disease patients Philippi, Nathalie Botzung, Anne Noblet, Vincent Rousseau, François Després, Olivier Cretin, Benjamin Kremer, Stéphane Blanc, Frédéric Manning, Liliann Front Aging Neurosci Neuroscience We studied the influence of emotions on autobiographical memory (AbM) in patients with Alzheimer’s disease (AD), characteristically triggering atrophy in the hippocampus and the amygdala, two crucial structures sustaining memory and emotional processing. Our first aim was to analyze the influence of emotion on AbM in AD patients, on both the proportion and the specificity of emotional memories. Additionally, we sought to determine the relationship of emotional AbM to amygdalar-hippocampal volumes. Eighteen prodromal to mild AD patients and 18 age-matched healthy controls were included. We obtained 30 autobiographical memories per participant using the modified Crovitz test (MCT). Analyses were performed on global scores, rates and specificity scores of the emotional vs. neutral categories of memories. Amygdalar-hippocampal volumes were extracted from 3D T1-weighted MRI scans and tested for correlations with behavioral data. Overall, AD patients displayed a deficit in emotional AbMs as they elicited less emotional memories than the controls, however, the specificity of those memories was preserved. The deficit likely implied retrieval or storage as it was extended in time and without reminiscence bump effect. Global scores and rates of emotional memories, but not the specificity scores, were correlated to right amygdalar and hippocampal volumes, indicating that atrophy in these structures has a central role in the deficit observed. Conversely, emotional memories were more specific than neutral memories in both groups, reflecting an enhancement effect of emotion that could be supported by other brain regions that are spared during the early stages of the disease. Frontiers Media S.A. 2015-03-16 /pmc/articles/PMC4360763/ /pubmed/25852541 http://dx.doi.org/10.3389/fnagi.2015.00021 Text en Copyright © 2015 Philippi, Botzung, Noblet, Rousseau, Després, Cretin, Kremer, Blanc and Manning. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Philippi, Nathalie
Botzung, Anne
Noblet, Vincent
Rousseau, François
Després, Olivier
Cretin, Benjamin
Kremer, Stéphane
Blanc, Frédéric
Manning, Liliann
Impaired emotional autobiographical memory associated with right amygdalar-hippocampal atrophy in Alzheimer’s disease patients
title Impaired emotional autobiographical memory associated with right amygdalar-hippocampal atrophy in Alzheimer’s disease patients
title_full Impaired emotional autobiographical memory associated with right amygdalar-hippocampal atrophy in Alzheimer’s disease patients
title_fullStr Impaired emotional autobiographical memory associated with right amygdalar-hippocampal atrophy in Alzheimer’s disease patients
title_full_unstemmed Impaired emotional autobiographical memory associated with right amygdalar-hippocampal atrophy in Alzheimer’s disease patients
title_short Impaired emotional autobiographical memory associated with right amygdalar-hippocampal atrophy in Alzheimer’s disease patients
title_sort impaired emotional autobiographical memory associated with right amygdalar-hippocampal atrophy in alzheimer’s disease patients
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4360763/
https://www.ncbi.nlm.nih.gov/pubmed/25852541
http://dx.doi.org/10.3389/fnagi.2015.00021
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