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Disease history and risk of comorbidity in women's life course: a comprehensive analysis of the Japan Nurses’ Health Study baseline survey

OBJECTIVE: To classify diseases based on age at peak incidence to identify risk factors for later disease in women's life course. DESIGN: A cross-sectional baseline survey of participants in the Japan Nurses’ Health Study. SETTING: A nationwide prospective cohort study on the health of Japanese...

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Autores principales: Nagai, Kazue, Hayashi, Kunihiko, Yasui, Toshiyuki, Katanoda, Kota, Iso, Hiroyasu, Kiyohara, Yutaka, Wakatsuki, Akihiko, Kubota, Toshiro, Mizunuma, Hideki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2015
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4360787/
https://www.ncbi.nlm.nih.gov/pubmed/25762230
http://dx.doi.org/10.1136/bmjopen-2014-006360
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author Nagai, Kazue
Hayashi, Kunihiko
Yasui, Toshiyuki
Katanoda, Kota
Iso, Hiroyasu
Kiyohara, Yutaka
Wakatsuki, Akihiko
Kubota, Toshiro
Mizunuma, Hideki
author_facet Nagai, Kazue
Hayashi, Kunihiko
Yasui, Toshiyuki
Katanoda, Kota
Iso, Hiroyasu
Kiyohara, Yutaka
Wakatsuki, Akihiko
Kubota, Toshiro
Mizunuma, Hideki
author_sort Nagai, Kazue
collection PubMed
description OBJECTIVE: To classify diseases based on age at peak incidence to identify risk factors for later disease in women's life course. DESIGN: A cross-sectional baseline survey of participants in the Japan Nurses’ Health Study. SETTING: A nationwide prospective cohort study on the health of Japanese nurses. The baseline survey was conducted between 2001 and 2007 (n=49 927). MAIN OUTCOME MEASURES: Age at peak incidence for 20 diseases from a survey of Japanese women was estimated using the Kaplan-Meier method with the Kernel smoothing technique. The incidence rate and peak incidence for diseases whose peak incidence occurred before the age of 45 years or before the perimenopausal period were selected as early-onset diseases. The OR and 95% CI were estimated to examine the risk of comorbidity between early-onset and other diseases. RESULTS: Four early-onset diseases (endometriosis, anaemia, migraine headache and uterine myoma) were significantly correlated with one another. Late-onset diseases significantly associated (OR>2) with early-onset diseases included comorbid endometriosis with ovarian cancer (3.65 (2.16 to 6.19)), endometrial cancer (2.40 (1.14 to 5.04)) and cerebral infarction (2.10 (1.15 to 3.85)); comorbid anaemia with gastric cancer (3.69 (2.68 to 5.08)); comorbid migraine with transient ischaemic attack (3.06 (2.29 to 4.09)), osteoporosis (2.11 (1.71 to 2.62)), cerebral infarction (2.04 (1.26 to 3.30)) and angina pectoris (2.00 (1.49 to 2.67)); and comorbid uterine myoma with colorectal cancer (2.31 (1.48 to 3.61)). CONCLUSIONS: While there were significant associations between four early-onset diseases, women with a history of one or more of the early-onset diseases had a higher risk of other diseases later in their life course. Understanding the history of early-onset diseases in women may help reduce the subsequent risk of chronic diseases in later life.
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spelling pubmed-43607872015-03-25 Disease history and risk of comorbidity in women's life course: a comprehensive analysis of the Japan Nurses’ Health Study baseline survey Nagai, Kazue Hayashi, Kunihiko Yasui, Toshiyuki Katanoda, Kota Iso, Hiroyasu Kiyohara, Yutaka Wakatsuki, Akihiko Kubota, Toshiro Mizunuma, Hideki BMJ Open Epidemiology OBJECTIVE: To classify diseases based on age at peak incidence to identify risk factors for later disease in women's life course. DESIGN: A cross-sectional baseline survey of participants in the Japan Nurses’ Health Study. SETTING: A nationwide prospective cohort study on the health of Japanese nurses. The baseline survey was conducted between 2001 and 2007 (n=49 927). MAIN OUTCOME MEASURES: Age at peak incidence for 20 diseases from a survey of Japanese women was estimated using the Kaplan-Meier method with the Kernel smoothing technique. The incidence rate and peak incidence for diseases whose peak incidence occurred before the age of 45 years or before the perimenopausal period were selected as early-onset diseases. The OR and 95% CI were estimated to examine the risk of comorbidity between early-onset and other diseases. RESULTS: Four early-onset diseases (endometriosis, anaemia, migraine headache and uterine myoma) were significantly correlated with one another. Late-onset diseases significantly associated (OR>2) with early-onset diseases included comorbid endometriosis with ovarian cancer (3.65 (2.16 to 6.19)), endometrial cancer (2.40 (1.14 to 5.04)) and cerebral infarction (2.10 (1.15 to 3.85)); comorbid anaemia with gastric cancer (3.69 (2.68 to 5.08)); comorbid migraine with transient ischaemic attack (3.06 (2.29 to 4.09)), osteoporosis (2.11 (1.71 to 2.62)), cerebral infarction (2.04 (1.26 to 3.30)) and angina pectoris (2.00 (1.49 to 2.67)); and comorbid uterine myoma with colorectal cancer (2.31 (1.48 to 3.61)). CONCLUSIONS: While there were significant associations between four early-onset diseases, women with a history of one or more of the early-onset diseases had a higher risk of other diseases later in their life course. Understanding the history of early-onset diseases in women may help reduce the subsequent risk of chronic diseases in later life. BMJ Publishing Group 2015-03-11 /pmc/articles/PMC4360787/ /pubmed/25762230 http://dx.doi.org/10.1136/bmjopen-2014-006360 Text en Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
spellingShingle Epidemiology
Nagai, Kazue
Hayashi, Kunihiko
Yasui, Toshiyuki
Katanoda, Kota
Iso, Hiroyasu
Kiyohara, Yutaka
Wakatsuki, Akihiko
Kubota, Toshiro
Mizunuma, Hideki
Disease history and risk of comorbidity in women's life course: a comprehensive analysis of the Japan Nurses’ Health Study baseline survey
title Disease history and risk of comorbidity in women's life course: a comprehensive analysis of the Japan Nurses’ Health Study baseline survey
title_full Disease history and risk of comorbidity in women's life course: a comprehensive analysis of the Japan Nurses’ Health Study baseline survey
title_fullStr Disease history and risk of comorbidity in women's life course: a comprehensive analysis of the Japan Nurses’ Health Study baseline survey
title_full_unstemmed Disease history and risk of comorbidity in women's life course: a comprehensive analysis of the Japan Nurses’ Health Study baseline survey
title_short Disease history and risk of comorbidity in women's life course: a comprehensive analysis of the Japan Nurses’ Health Study baseline survey
title_sort disease history and risk of comorbidity in women's life course: a comprehensive analysis of the japan nurses’ health study baseline survey
topic Epidemiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4360787/
https://www.ncbi.nlm.nih.gov/pubmed/25762230
http://dx.doi.org/10.1136/bmjopen-2014-006360
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