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Cellular targets for neuropeptide Y-mediated control of adult neurogenesis

Neuropeptides are emerging as key regulators of stem cell niche activities in health and disease, both inside and outside the central nervous system (CNS). Among them, neuropeptide Y (NPY), one of the most abundant neuropeptides both in the nervous system and in non-neural districts, has become the...

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Autores principales: Geloso, Maria Concetta, Corvino, Valentina, Di Maria, Valentina, Marchese, Elisa, Michetti, Fabrizio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4360818/
https://www.ncbi.nlm.nih.gov/pubmed/25852477
http://dx.doi.org/10.3389/fncel.2015.00085
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author Geloso, Maria Concetta
Corvino, Valentina
Di Maria, Valentina
Marchese, Elisa
Michetti, Fabrizio
author_facet Geloso, Maria Concetta
Corvino, Valentina
Di Maria, Valentina
Marchese, Elisa
Michetti, Fabrizio
author_sort Geloso, Maria Concetta
collection PubMed
description Neuropeptides are emerging as key regulators of stem cell niche activities in health and disease, both inside and outside the central nervous system (CNS). Among them, neuropeptide Y (NPY), one of the most abundant neuropeptides both in the nervous system and in non-neural districts, has become the focus of much attention for its involvement in a wide range of physiological and pathological conditions, including the modulation of different stem cell activities. In particular, a pro-neurogenic role of NPY has been evidenced in the neurogenic niche, where a direct effect on neural progenitors has been demonstrated, while different cellular types, including astrocytes, microglia and endothelial cells, also appear to be responsive to the peptide. The marked modulation of the NPY system during several pathological conditions that affect neurogenesis, including stress, seizures and neurodegeneration, further highlights the relevance of this peptide in the regulation of adult neurogenesis. In view of the considerable interest in understanding the mechanisms controlling neural cell fate, this review aims to summarize and discuss current data on NPY signaling in the different cellular components of the neurogenic niche in order to elucidate the complexity of the mechanisms underlying the modulatory properties of this peptide.
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spelling pubmed-43608182015-04-07 Cellular targets for neuropeptide Y-mediated control of adult neurogenesis Geloso, Maria Concetta Corvino, Valentina Di Maria, Valentina Marchese, Elisa Michetti, Fabrizio Front Cell Neurosci Neuroscience Neuropeptides are emerging as key regulators of stem cell niche activities in health and disease, both inside and outside the central nervous system (CNS). Among them, neuropeptide Y (NPY), one of the most abundant neuropeptides both in the nervous system and in non-neural districts, has become the focus of much attention for its involvement in a wide range of physiological and pathological conditions, including the modulation of different stem cell activities. In particular, a pro-neurogenic role of NPY has been evidenced in the neurogenic niche, where a direct effect on neural progenitors has been demonstrated, while different cellular types, including astrocytes, microglia and endothelial cells, also appear to be responsive to the peptide. The marked modulation of the NPY system during several pathological conditions that affect neurogenesis, including stress, seizures and neurodegeneration, further highlights the relevance of this peptide in the regulation of adult neurogenesis. In view of the considerable interest in understanding the mechanisms controlling neural cell fate, this review aims to summarize and discuss current data on NPY signaling in the different cellular components of the neurogenic niche in order to elucidate the complexity of the mechanisms underlying the modulatory properties of this peptide. Frontiers Media S.A. 2015-03-16 /pmc/articles/PMC4360818/ /pubmed/25852477 http://dx.doi.org/10.3389/fncel.2015.00085 Text en Copyright © 2015 Geloso, Corvino, Di Maria, Marchese and Michetti. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Geloso, Maria Concetta
Corvino, Valentina
Di Maria, Valentina
Marchese, Elisa
Michetti, Fabrizio
Cellular targets for neuropeptide Y-mediated control of adult neurogenesis
title Cellular targets for neuropeptide Y-mediated control of adult neurogenesis
title_full Cellular targets for neuropeptide Y-mediated control of adult neurogenesis
title_fullStr Cellular targets for neuropeptide Y-mediated control of adult neurogenesis
title_full_unstemmed Cellular targets for neuropeptide Y-mediated control of adult neurogenesis
title_short Cellular targets for neuropeptide Y-mediated control of adult neurogenesis
title_sort cellular targets for neuropeptide y-mediated control of adult neurogenesis
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4360818/
https://www.ncbi.nlm.nih.gov/pubmed/25852477
http://dx.doi.org/10.3389/fncel.2015.00085
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