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Secretion of salivary statherin is compromised in uncontrolled diabetic patients
BACKGROUND: Statherin is an important salivary protein for maintaining oral health. The purpose of the current study was to determine if differences in statherin levels exist between diabetic and healthy subjects. METHODS: A total of 48 diabetic and healthy controls were randomly selected from a com...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4360915/ https://www.ncbi.nlm.nih.gov/pubmed/25793156 http://dx.doi.org/10.1016/j.bbacli.2015.01.002 |
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author | Izumi, Masahiro Zhang, Bin-Xian Dean, David D. Lin, Alan L. Saunders, Michèle J. Hazuda, Helen P. Yeh, Chih-Ko |
author_facet | Izumi, Masahiro Zhang, Bin-Xian Dean, David D. Lin, Alan L. Saunders, Michèle J. Hazuda, Helen P. Yeh, Chih-Ko |
author_sort | Izumi, Masahiro |
collection | PubMed |
description | BACKGROUND: Statherin is an important salivary protein for maintaining oral health. The purpose of the current study was to determine if differences in statherin levels exist between diabetic and healthy subjects. METHODS: A total of 48 diabetic and healthy controls were randomly selected from a community-based database. Diabetic subjects (n = 24) had fasting glucose levels > 180 mg/dL, while controls (n = 24) had levels < 110 mg/dL. Parotid saliva (PS) and sublingual/submandibular saliva (SS) were collected and salivary flow rates determined. Salivary statherin levels were determined by densitometry of Western blots. Blood hemoglobin A1c (HbA1c) and total protein in saliva were also obtained. RESULTS: SS, but not PS, salivary flow rate and total protein in diabetics were significantly less than those in healthy controls (p = 0.021 & p < 0.001 respectively). Correlation analysis revealed the existence of a negative correlation between PS statherin levels and HbA1c (p = 0.012) and fasting glucose (p = 0.021) levels, while no such correlation was found for SS statherin levels. When statherin levels were normalized to total salivary protein, the proportion of PS statherin, but not SS statherin, in diabetics was significantly less than that in controls (p = 0.032). In contrast, the amount of statherin secretion in SS, but not PS, was significantly decreased in diabetics compared to controls (p = 0.016). CONCLUSIONS AND GENERAL SIGNIFICANCE: The results show that synthesis and secretion of statherin is reduced in diabetics and this reduction is salivary gland specific. As compromised salivary statherin secretion leads to increased oral health risk, this study indicates that routine oral health assessment of these patients is warranted. |
format | Online Article Text |
id | pubmed-4360915 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-43609152015-12-15 Secretion of salivary statherin is compromised in uncontrolled diabetic patients Izumi, Masahiro Zhang, Bin-Xian Dean, David D. Lin, Alan L. Saunders, Michèle J. Hazuda, Helen P. Yeh, Chih-Ko BBA Clin Regular Article BACKGROUND: Statherin is an important salivary protein for maintaining oral health. The purpose of the current study was to determine if differences in statherin levels exist between diabetic and healthy subjects. METHODS: A total of 48 diabetic and healthy controls were randomly selected from a community-based database. Diabetic subjects (n = 24) had fasting glucose levels > 180 mg/dL, while controls (n = 24) had levels < 110 mg/dL. Parotid saliva (PS) and sublingual/submandibular saliva (SS) were collected and salivary flow rates determined. Salivary statherin levels were determined by densitometry of Western blots. Blood hemoglobin A1c (HbA1c) and total protein in saliva were also obtained. RESULTS: SS, but not PS, salivary flow rate and total protein in diabetics were significantly less than those in healthy controls (p = 0.021 & p < 0.001 respectively). Correlation analysis revealed the existence of a negative correlation between PS statherin levels and HbA1c (p = 0.012) and fasting glucose (p = 0.021) levels, while no such correlation was found for SS statherin levels. When statherin levels were normalized to total salivary protein, the proportion of PS statherin, but not SS statherin, in diabetics was significantly less than that in controls (p = 0.032). In contrast, the amount of statherin secretion in SS, but not PS, was significantly decreased in diabetics compared to controls (p = 0.016). CONCLUSIONS AND GENERAL SIGNIFICANCE: The results show that synthesis and secretion of statherin is reduced in diabetics and this reduction is salivary gland specific. As compromised salivary statherin secretion leads to increased oral health risk, this study indicates that routine oral health assessment of these patients is warranted. Elsevier 2015-01-15 /pmc/articles/PMC4360915/ /pubmed/25793156 http://dx.doi.org/10.1016/j.bbacli.2015.01.002 Text en http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Regular Article Izumi, Masahiro Zhang, Bin-Xian Dean, David D. Lin, Alan L. Saunders, Michèle J. Hazuda, Helen P. Yeh, Chih-Ko Secretion of salivary statherin is compromised in uncontrolled diabetic patients |
title | Secretion of salivary statherin is compromised in uncontrolled diabetic patients |
title_full | Secretion of salivary statherin is compromised in uncontrolled diabetic patients |
title_fullStr | Secretion of salivary statherin is compromised in uncontrolled diabetic patients |
title_full_unstemmed | Secretion of salivary statherin is compromised in uncontrolled diabetic patients |
title_short | Secretion of salivary statherin is compromised in uncontrolled diabetic patients |
title_sort | secretion of salivary statherin is compromised in uncontrolled diabetic patients |
topic | Regular Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4360915/ https://www.ncbi.nlm.nih.gov/pubmed/25793156 http://dx.doi.org/10.1016/j.bbacli.2015.01.002 |
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