Kidney disease as a determinant of cognitive decline and dementia

Chronic kidney disease (CKD) has evolved as a possible new determinant of cognitive decline and dementia. This review outlines the presumed pathophysiology of cognitive decline in CKD, which consists of traditional and new vascular risk factors as well as nonvascular risk factors and metabolic and b...

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Detalles Bibliográficos
Autor principal: Etgen, Thorleif
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4360943/
https://www.ncbi.nlm.nih.gov/pubmed/25780391
http://dx.doi.org/10.1186/s13195-015-0115-4
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author Etgen, Thorleif
author_facet Etgen, Thorleif
author_sort Etgen, Thorleif
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description Chronic kidney disease (CKD) has evolved as a possible new determinant of cognitive decline and dementia. This review outlines the presumed pathophysiology of cognitive decline in CKD, which consists of traditional and new vascular risk factors as well as nonvascular risk factors and metabolic and biochemical abnormalities within the central nervous system caused by CKD. The recent major cross-sectional studies and longitudinal studies – including one meta-analysis – that mostly suggest an association of cognitive decline and CKD are discussed. Finally, potential therapeutic strategies are presented.
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spelling pubmed-43609432015-03-17 Kidney disease as a determinant of cognitive decline and dementia Etgen, Thorleif Alzheimers Res Ther Review Chronic kidney disease (CKD) has evolved as a possible new determinant of cognitive decline and dementia. This review outlines the presumed pathophysiology of cognitive decline in CKD, which consists of traditional and new vascular risk factors as well as nonvascular risk factors and metabolic and biochemical abnormalities within the central nervous system caused by CKD. The recent major cross-sectional studies and longitudinal studies – including one meta-analysis – that mostly suggest an association of cognitive decline and CKD are discussed. Finally, potential therapeutic strategies are presented. BioMed Central 2015-03-17 /pmc/articles/PMC4360943/ /pubmed/25780391 http://dx.doi.org/10.1186/s13195-015-0115-4 Text en © Etgen; licensee BioMed Central. 2015 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Etgen, Thorleif
Kidney disease as a determinant of cognitive decline and dementia
title Kidney disease as a determinant of cognitive decline and dementia
title_full Kidney disease as a determinant of cognitive decline and dementia
title_fullStr Kidney disease as a determinant of cognitive decline and dementia
title_full_unstemmed Kidney disease as a determinant of cognitive decline and dementia
title_short Kidney disease as a determinant of cognitive decline and dementia
title_sort kidney disease as a determinant of cognitive decline and dementia
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4360943/
https://www.ncbi.nlm.nih.gov/pubmed/25780391
http://dx.doi.org/10.1186/s13195-015-0115-4
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