In silico discovery and validation of potent small-molecule inhibitors targeting the activation function 2 site of human oestrogen receptor α

INTRODUCTION: Current approaches to inhibit oestrogen receptor-alpha (ERα) are focused on targeting its hormone-binding pocket and have limitations. Thus, we propose that inhibitors that bind to a coactivator-binding pocket on ERα, called activation function 2 (AF2), might overcome some of these lim...

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Detalles Bibliográficos
Autores principales: Singh, Kriti, Munuganti, Ravi Shashi Nayana, Leblanc, Eric, Lin, Yu Lun, Leung, Euphemia, Lallous, Nada, Butler, Miriam, Cherkasov, Artem, Rennie, Paul S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4360945/
https://www.ncbi.nlm.nih.gov/pubmed/25848700
http://dx.doi.org/10.1186/s13058-015-0529-8

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