The systemic delivery of an oncolytic adenovirus expressing decorin inhibits bone metastasis in a mouse model of human prostate cancer

In an effort to develop a new therapy for prostate cancer bone metastases, we have created Ad.dcn, a recombinant oncolytic adenovirus carrying the human decorin gene. Infection of PC-3 and DU-145, the human prostate tumor cells, with Ad.dcn or a non-replicating adenovirus Ad(E1-).dcn resulted in dec...

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Detalles Bibliográficos
Autores principales: Xu, Weidong, Neill, Thomas, Yang, Yuefeng, Hu, Zebin, Cleveland, Elyse, Wu, Ying, Hutten, Ryan, Xiao, Xianghui, Stock, Stuart R., Shevrin, Daniel, Kaul, Karen, Brendler, Charles, Iozzo, Renato V., Seth, Prem
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4361227/
https://www.ncbi.nlm.nih.gov/pubmed/25503693
http://dx.doi.org/10.1038/gt.2014.110

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