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The Neuroanatomical Basis of Panic Disorder and Social Phobia in Schizophrenia: A Voxel Based Morphometric Study

OBJECTIVE: It is known that there is a high prevalence of certain anxiety disorders among schizophrenic patients, especially panic disorder and social phobia. However, the neural underpinnings of the comorbidity of such anxiety disorders and schizophrenia remain unclear. Our study aims to determine...

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Autores principales: Picado, Marisol, Carmona, Susanna, Hoekzema, Elseline, Pailhez, Guillem, Bergé, Daniel, Mané, Anna, Fauquet, Jordi, Hilferty, Joseph, Moreno, Ana, Cortizo, Romina, Vilarroya, Oscar, Bulbena, Antoni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4361479/
https://www.ncbi.nlm.nih.gov/pubmed/25774979
http://dx.doi.org/10.1371/journal.pone.0119847
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author Picado, Marisol
Carmona, Susanna
Hoekzema, Elseline
Pailhez, Guillem
Bergé, Daniel
Mané, Anna
Fauquet, Jordi
Hilferty, Joseph
Moreno, Ana
Cortizo, Romina
Vilarroya, Oscar
Bulbena, Antoni
author_facet Picado, Marisol
Carmona, Susanna
Hoekzema, Elseline
Pailhez, Guillem
Bergé, Daniel
Mané, Anna
Fauquet, Jordi
Hilferty, Joseph
Moreno, Ana
Cortizo, Romina
Vilarroya, Oscar
Bulbena, Antoni
author_sort Picado, Marisol
collection PubMed
description OBJECTIVE: It is known that there is a high prevalence of certain anxiety disorders among schizophrenic patients, especially panic disorder and social phobia. However, the neural underpinnings of the comorbidity of such anxiety disorders and schizophrenia remain unclear. Our study aims to determine the neuroanatomical basis of the co-occurrence of schizophrenia with panic disorder and social phobia. METHODS: Voxel-based morphometry was used in order to examine brain structure and to measure between-group differences, comparing magnetic resonance images of 20 anxious patients, 20 schizophrenic patients, 20 schizophrenic patients with comorbid anxiety, and 20 healthy control subjects. RESULTS: Compared to the schizophrenic patients, we observed smaller grey-matter volume (GMV) decreases in the dorsolateral prefrontal cortex and precentral gyrus in the schizophrenic-anxiety group. Additionally, the schizophrenic group showed significantly reduced GMV in the dorsolateral prefrontal cortex, precentral gyrus, orbitofrontal cortex, temporal gyrus and angular/inferior parietal gyrus when compared to the control group. CONCLUSIONS: Our findings suggest that the comorbidity of schizophrenia with panic disorder and social phobia might be characterized by specific neuroanatomical and clinical alterations that may be related to maladaptive emotion regulation related to anxiety. Even thought our findings need to be replicated, our study suggests that the identification of neural abnormalities involved in anxiety, schizophrenia and schizophrenia-anxiety may lead to an improved diagnosis and management of these conditions.
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spelling pubmed-43614792015-03-23 The Neuroanatomical Basis of Panic Disorder and Social Phobia in Schizophrenia: A Voxel Based Morphometric Study Picado, Marisol Carmona, Susanna Hoekzema, Elseline Pailhez, Guillem Bergé, Daniel Mané, Anna Fauquet, Jordi Hilferty, Joseph Moreno, Ana Cortizo, Romina Vilarroya, Oscar Bulbena, Antoni PLoS One Research Article OBJECTIVE: It is known that there is a high prevalence of certain anxiety disorders among schizophrenic patients, especially panic disorder and social phobia. However, the neural underpinnings of the comorbidity of such anxiety disorders and schizophrenia remain unclear. Our study aims to determine the neuroanatomical basis of the co-occurrence of schizophrenia with panic disorder and social phobia. METHODS: Voxel-based morphometry was used in order to examine brain structure and to measure between-group differences, comparing magnetic resonance images of 20 anxious patients, 20 schizophrenic patients, 20 schizophrenic patients with comorbid anxiety, and 20 healthy control subjects. RESULTS: Compared to the schizophrenic patients, we observed smaller grey-matter volume (GMV) decreases in the dorsolateral prefrontal cortex and precentral gyrus in the schizophrenic-anxiety group. Additionally, the schizophrenic group showed significantly reduced GMV in the dorsolateral prefrontal cortex, precentral gyrus, orbitofrontal cortex, temporal gyrus and angular/inferior parietal gyrus when compared to the control group. CONCLUSIONS: Our findings suggest that the comorbidity of schizophrenia with panic disorder and social phobia might be characterized by specific neuroanatomical and clinical alterations that may be related to maladaptive emotion regulation related to anxiety. Even thought our findings need to be replicated, our study suggests that the identification of neural abnormalities involved in anxiety, schizophrenia and schizophrenia-anxiety may lead to an improved diagnosis and management of these conditions. Public Library of Science 2015-03-16 /pmc/articles/PMC4361479/ /pubmed/25774979 http://dx.doi.org/10.1371/journal.pone.0119847 Text en © 2015 Picado et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Picado, Marisol
Carmona, Susanna
Hoekzema, Elseline
Pailhez, Guillem
Bergé, Daniel
Mané, Anna
Fauquet, Jordi
Hilferty, Joseph
Moreno, Ana
Cortizo, Romina
Vilarroya, Oscar
Bulbena, Antoni
The Neuroanatomical Basis of Panic Disorder and Social Phobia in Schizophrenia: A Voxel Based Morphometric Study
title The Neuroanatomical Basis of Panic Disorder and Social Phobia in Schizophrenia: A Voxel Based Morphometric Study
title_full The Neuroanatomical Basis of Panic Disorder and Social Phobia in Schizophrenia: A Voxel Based Morphometric Study
title_fullStr The Neuroanatomical Basis of Panic Disorder and Social Phobia in Schizophrenia: A Voxel Based Morphometric Study
title_full_unstemmed The Neuroanatomical Basis of Panic Disorder and Social Phobia in Schizophrenia: A Voxel Based Morphometric Study
title_short The Neuroanatomical Basis of Panic Disorder and Social Phobia in Schizophrenia: A Voxel Based Morphometric Study
title_sort neuroanatomical basis of panic disorder and social phobia in schizophrenia: a voxel based morphometric study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4361479/
https://www.ncbi.nlm.nih.gov/pubmed/25774979
http://dx.doi.org/10.1371/journal.pone.0119847
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