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Quantification of Histone H3 Lys27 Trimethylation (H3K27me3) by High-Throughput Microscopy Enables Cellular Large-Scale Screening for Small-Molecule EZH2 Inhibitors

EZH2 inhibition can decrease global histone H3 lysine 27 trimethylation (H3K27me3) and thereby reactivates silenced tumor suppressor genes. Inhibition of EZH2 is regarded as an option for therapeutic cancer intervention. To identify novel small-molecule (SMOL) inhibitors of EZH2 in drug discovery, t...

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Detalles Bibliográficos
Autores principales:	Luense, Svenja, Denner, Philip, Fernández-Montalván, Amaury, Hartung, Ingo, Husemann, Manfred, Stresemann, Carlo, Prechtl, Stefan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	SAGE Publications 2015
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4361481/ https://www.ncbi.nlm.nih.gov/pubmed/25409661 http://dx.doi.org/10.1177/1087057114559668

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