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Impact of the Distance from the Stent Edge to the Residual Plaque on Edge Restenosis following Everolimus-Eluting Stent Implantation
OBJECTIVES: This study aimed to assess the relation between stent edge restenosis (SER) and the distance from the stent edge to the residual plaque using quantitative intravascular ultrasound. BACKGROUND: Although percutaneous coronary intervention with drug-eluting stents has improved SER rates, de...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4361545/ https://www.ncbi.nlm.nih.gov/pubmed/25775115 http://dx.doi.org/10.1371/journal.pone.0121079 |
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author | Takahashi, Masao Miyazaki, Susumu Myojo, Masahiro Sawaki, Daigo Iwata, Hiroshi Kiyosue, Arihiro Higashikuni, Yasutomi Tanaka, Tomofumi Fujita, Daishi Ando, Jiro Fujita, Hideo Hirata, Yasunobu Komuro, Issei |
author_facet | Takahashi, Masao Miyazaki, Susumu Myojo, Masahiro Sawaki, Daigo Iwata, Hiroshi Kiyosue, Arihiro Higashikuni, Yasutomi Tanaka, Tomofumi Fujita, Daishi Ando, Jiro Fujita, Hideo Hirata, Yasunobu Komuro, Issei |
author_sort | Takahashi, Masao |
collection | PubMed |
description | OBJECTIVES: This study aimed to assess the relation between stent edge restenosis (SER) and the distance from the stent edge to the residual plaque using quantitative intravascular ultrasound. BACKGROUND: Although percutaneous coronary intervention with drug-eluting stents has improved SER rates, determining an appropriate stent edge landing zone can be challenging in cases of diffuse plaque lesions. It is known that edge vascular response can occur within 2 mm from the edge of a bare metal stent, but the distance to the adjacent plaque has not been evaluated for drug-eluting stents. METHODS: A total of 97 proximal residual plaque lesions (plaque burden [PB] >40%) treated with everolimus-eluting stents were retrospectively evaluated to determine the distance from the stent edge to the residual plaque. RESULTS: The SER group had significantly higher PB (59.1 ± 6.1% vs. 51.9 ± 9.1% for non-SER; P = 0.04). Higher PB was associated with SER, with the cutoff value of 54.74% determined using receiver operating characteristic (ROC) curve analysis. At this cutoff value of PB, the distance from the stent edge to the lesion was significantly associated with SER (odds ratio = 2.05, P = 0.035). The corresponding area under the ROC curve was 0.725, and the cutoff distance value for predicting SER was 1.0 mm. CONCLUSION: An interval less than 1 mm from the proximal stent edge to the nearest point with the determined PB cutoff value of 54.74% was significantly associated with SER in patients with residual plaque lesions. |
format | Online Article Text |
id | pubmed-4361545 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-43615452015-03-23 Impact of the Distance from the Stent Edge to the Residual Plaque on Edge Restenosis following Everolimus-Eluting Stent Implantation Takahashi, Masao Miyazaki, Susumu Myojo, Masahiro Sawaki, Daigo Iwata, Hiroshi Kiyosue, Arihiro Higashikuni, Yasutomi Tanaka, Tomofumi Fujita, Daishi Ando, Jiro Fujita, Hideo Hirata, Yasunobu Komuro, Issei PLoS One Research Article OBJECTIVES: This study aimed to assess the relation between stent edge restenosis (SER) and the distance from the stent edge to the residual plaque using quantitative intravascular ultrasound. BACKGROUND: Although percutaneous coronary intervention with drug-eluting stents has improved SER rates, determining an appropriate stent edge landing zone can be challenging in cases of diffuse plaque lesions. It is known that edge vascular response can occur within 2 mm from the edge of a bare metal stent, but the distance to the adjacent plaque has not been evaluated for drug-eluting stents. METHODS: A total of 97 proximal residual plaque lesions (plaque burden [PB] >40%) treated with everolimus-eluting stents were retrospectively evaluated to determine the distance from the stent edge to the residual plaque. RESULTS: The SER group had significantly higher PB (59.1 ± 6.1% vs. 51.9 ± 9.1% for non-SER; P = 0.04). Higher PB was associated with SER, with the cutoff value of 54.74% determined using receiver operating characteristic (ROC) curve analysis. At this cutoff value of PB, the distance from the stent edge to the lesion was significantly associated with SER (odds ratio = 2.05, P = 0.035). The corresponding area under the ROC curve was 0.725, and the cutoff distance value for predicting SER was 1.0 mm. CONCLUSION: An interval less than 1 mm from the proximal stent edge to the nearest point with the determined PB cutoff value of 54.74% was significantly associated with SER in patients with residual plaque lesions. Public Library of Science 2015-03-16 /pmc/articles/PMC4361545/ /pubmed/25775115 http://dx.doi.org/10.1371/journal.pone.0121079 Text en © 2015 Takahashi et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Takahashi, Masao Miyazaki, Susumu Myojo, Masahiro Sawaki, Daigo Iwata, Hiroshi Kiyosue, Arihiro Higashikuni, Yasutomi Tanaka, Tomofumi Fujita, Daishi Ando, Jiro Fujita, Hideo Hirata, Yasunobu Komuro, Issei Impact of the Distance from the Stent Edge to the Residual Plaque on Edge Restenosis following Everolimus-Eluting Stent Implantation |
title | Impact of the Distance from the Stent Edge to the Residual Plaque on Edge Restenosis following Everolimus-Eluting Stent Implantation |
title_full | Impact of the Distance from the Stent Edge to the Residual Plaque on Edge Restenosis following Everolimus-Eluting Stent Implantation |
title_fullStr | Impact of the Distance from the Stent Edge to the Residual Plaque on Edge Restenosis following Everolimus-Eluting Stent Implantation |
title_full_unstemmed | Impact of the Distance from the Stent Edge to the Residual Plaque on Edge Restenosis following Everolimus-Eluting Stent Implantation |
title_short | Impact of the Distance from the Stent Edge to the Residual Plaque on Edge Restenosis following Everolimus-Eluting Stent Implantation |
title_sort | impact of the distance from the stent edge to the residual plaque on edge restenosis following everolimus-eluting stent implantation |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4361545/ https://www.ncbi.nlm.nih.gov/pubmed/25775115 http://dx.doi.org/10.1371/journal.pone.0121079 |
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