Hedgehog Signaling Pathway Is Active in GBM with GLI1 mRNA Expression Showing a Single Continuous Distribution Rather than Discrete High/Low Clusters

Hedgehog (Hh) signaling pathway is a valid therapeutic target in a wide range of malignancies. We focus here on glioblastoma multiforme (GBM), a lethal malignancy of the central nervous system (CNS). By analyzing RNA-sequencing based transcriptomics data on 149 clinical cases of TCGA-GBM database we...

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Detalles Bibliográficos
Autores principales: Chandra, Vikas, Das, Tapojyoti, Gulati, Puneet, Biswas, Nidhan K., Rote, Sarang, Chatterjee, Uttara, Ghosh, Samarendra N., Deb, Sumit, Saha, Suniti K., Chowdhury, Anup K., Ghosh, Subhashish, Rudin, Charles M., Mukherjee, Ankur, Basu, Analabha, Dhara, Surajit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4361547/
https://www.ncbi.nlm.nih.gov/pubmed/25775002
http://dx.doi.org/10.1371/journal.pone.0116390

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