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Causal Drift, Robust Signaling, and Complex Disease
The phenotype of many regulatory circuits in which mutations can cause complex, polygenic diseases is to some extent robust to DNA mutations that affect circuit components. Here I demonstrate how such mutational robustness can prevent the discovery of genetic disease determinants. To make my case, I...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2015
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4361548/ https://www.ncbi.nlm.nih.gov/pubmed/25774510 http://dx.doi.org/10.1371/journal.pone.0118413 |