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The Nuclear Receptor DAF-12 Regulates Nutrient Metabolism and Reproductive Growth in Nematodes
Appropriate nutrient response is essential for growth and reproduction. Under favorable nutrient conditions, the C. elegans nuclear receptor DAF-12 is activated by dafachronic acids, hormones that commit larvae to reproductive growth. Here, we report that in addition to its well-studied role in cont...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4361679/ https://www.ncbi.nlm.nih.gov/pubmed/25774872 http://dx.doi.org/10.1371/journal.pgen.1005027 |
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author | Wang, Zhu Stoltzfus, Jonathan You, Young-jai Ranjit, Najju Tang, Hao Xie, Yang Lok, James B. Mangelsdorf, David J. Kliewer, Steven A. |
author_facet | Wang, Zhu Stoltzfus, Jonathan You, Young-jai Ranjit, Najju Tang, Hao Xie, Yang Lok, James B. Mangelsdorf, David J. Kliewer, Steven A. |
author_sort | Wang, Zhu |
collection | PubMed |
description | Appropriate nutrient response is essential for growth and reproduction. Under favorable nutrient conditions, the C. elegans nuclear receptor DAF-12 is activated by dafachronic acids, hormones that commit larvae to reproductive growth. Here, we report that in addition to its well-studied role in controlling developmental gene expression, the DAF-12 endocrine system governs expression of a gene network that stimulates the aerobic catabolism of fatty acids. Thus, activation of the DAF-12 transcriptome coordinately mobilizes energy stores to permit reproductive growth. DAF-12 regulation of this metabolic gene network is conserved in the human parasite, Strongyloides stercoralis, and inhibition of specific steps in this network blocks reproductive growth in both of the nematodes. Our study provides a molecular understanding for metabolic adaptation of nematodes to their environment, and suggests a new therapeutic strategy for treating parasitic diseases. |
format | Online Article Text |
id | pubmed-4361679 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-43616792015-03-23 The Nuclear Receptor DAF-12 Regulates Nutrient Metabolism and Reproductive Growth in Nematodes Wang, Zhu Stoltzfus, Jonathan You, Young-jai Ranjit, Najju Tang, Hao Xie, Yang Lok, James B. Mangelsdorf, David J. Kliewer, Steven A. PLoS Genet Research Article Appropriate nutrient response is essential for growth and reproduction. Under favorable nutrient conditions, the C. elegans nuclear receptor DAF-12 is activated by dafachronic acids, hormones that commit larvae to reproductive growth. Here, we report that in addition to its well-studied role in controlling developmental gene expression, the DAF-12 endocrine system governs expression of a gene network that stimulates the aerobic catabolism of fatty acids. Thus, activation of the DAF-12 transcriptome coordinately mobilizes energy stores to permit reproductive growth. DAF-12 regulation of this metabolic gene network is conserved in the human parasite, Strongyloides stercoralis, and inhibition of specific steps in this network blocks reproductive growth in both of the nematodes. Our study provides a molecular understanding for metabolic adaptation of nematodes to their environment, and suggests a new therapeutic strategy for treating parasitic diseases. Public Library of Science 2015-03-16 /pmc/articles/PMC4361679/ /pubmed/25774872 http://dx.doi.org/10.1371/journal.pgen.1005027 Text en © 2015 Wang et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Wang, Zhu Stoltzfus, Jonathan You, Young-jai Ranjit, Najju Tang, Hao Xie, Yang Lok, James B. Mangelsdorf, David J. Kliewer, Steven A. The Nuclear Receptor DAF-12 Regulates Nutrient Metabolism and Reproductive Growth in Nematodes |
title | The Nuclear Receptor DAF-12 Regulates Nutrient Metabolism and Reproductive Growth in Nematodes |
title_full | The Nuclear Receptor DAF-12 Regulates Nutrient Metabolism and Reproductive Growth in Nematodes |
title_fullStr | The Nuclear Receptor DAF-12 Regulates Nutrient Metabolism and Reproductive Growth in Nematodes |
title_full_unstemmed | The Nuclear Receptor DAF-12 Regulates Nutrient Metabolism and Reproductive Growth in Nematodes |
title_short | The Nuclear Receptor DAF-12 Regulates Nutrient Metabolism and Reproductive Growth in Nematodes |
title_sort | nuclear receptor daf-12 regulates nutrient metabolism and reproductive growth in nematodes |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4361679/ https://www.ncbi.nlm.nih.gov/pubmed/25774872 http://dx.doi.org/10.1371/journal.pgen.1005027 |
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