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Synthesis and Fluorescence Properties of New Ester Derivatives of Isothiazolo [4,5-b] Pyridine
A two new compounds with potential biologically active were synthesized: ethyl 4-(2H-4,6-dimethyl-3-oxo-2,3-dihydroisothiazolo [5,4-b] pyridin-2-yl) butanoate and ethyl 4-(2H-4,6-dimethyl-2,3-dihydroisothiazolo [5,4-b] pyridin-3-yloxy) butanoate. The structures of all of the newly formed compounds w...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer US
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4361752/ https://www.ncbi.nlm.nih.gov/pubmed/25612854 http://dx.doi.org/10.1007/s10895-015-1504-6 |
Sumario: | A two new compounds with potential biologically active were synthesized: ethyl 4-(2H-4,6-dimethyl-3-oxo-2,3-dihydroisothiazolo [5,4-b] pyridin-2-yl) butanoate and ethyl 4-(2H-4,6-dimethyl-2,3-dihydroisothiazolo [5,4-b] pyridin-3-yloxy) butanoate. The structures of all of the newly formed compounds were identified by elemental analysis, FTIR and (1)H NMR. Their optical properties were studied in ethanol and n-hexane by UV–Vis absorption and fluorescence spectroscopy. The ground-state and excited-state properties were investigated using the density functional theory (DFT) and the time-dependent density functional theory (TDDFT) methods. The results showed differences between emission spectra in ethanol and n-hexane solution (solvatochromism) for both new compounds. |
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