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The Effect of Isotretinoin (Roaccutane) Therapy on Depression and Quality of Life of Patients with Severe Acne

OBJECTIVE: Acne is the most common skin disease and isotretinoin is the most powerful drug among the various drugs used for its treatment, but it has some adverse effects. The aim of this study was to evaluate the effect of isotretinoin on depression and quality of life of a group of patients underg...

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Autores principales: Fakour, Youssef, Noormohammadpour, Pedram, Ameri, Hamed, Ehsani, Amir Houshang, Mokhtari, Leila, Khosrovanmehr, Najmeh, Hoseini nezhad, Seyedeh Zahra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Tehran University of Medical Sciences 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4361827/
https://www.ncbi.nlm.nih.gov/pubmed/25792992
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author Fakour, Youssef
Noormohammadpour, Pedram
Ameri, Hamed
Ehsani, Amir Houshang
Mokhtari, Leila
Khosrovanmehr, Najmeh
Hoseini nezhad, Seyedeh Zahra
author_facet Fakour, Youssef
Noormohammadpour, Pedram
Ameri, Hamed
Ehsani, Amir Houshang
Mokhtari, Leila
Khosrovanmehr, Najmeh
Hoseini nezhad, Seyedeh Zahra
author_sort Fakour, Youssef
collection PubMed
description OBJECTIVE: Acne is the most common skin disease and isotretinoin is the most powerful drug among the various drugs used for its treatment, but it has some adverse effects. The aim of this study was to evaluate the effect of isotretinoin on depression and quality of life of a group of patients undergoing isotretinoin therapy before and after the treatment course. METHODS: In this prospective study, 98 patients with severe acne were enrolled consecutively and underwent isotretinoin therapy receiving 0.5 mg/kg/d of isotretinoin for 16 weeks. Isotretinoin effects on quality of life and depression were evaluated using Dermatology Life Quality Index (DLQI) and Beck Depression Inventory (BDI) questionnaires, respectively. RESULTS: In this study, 98 patients suffering from severe acne (38 males and 60 females) were enrolled. Treatment of acne was associated with improvement of quality of life scores in both male and female patients (p = 0.001). Considering the cutoff value of 13 for mild depressive mood in the BDI score, in total, 48 (49%) of the enrolled patients (21 males and 33 females) had a mild depressive mood before the commencement of the treatment in this study. The analysis of before and after treatment BDI scores showed that the number of patients and also the mean score of BDI were increased in both male and female patients after the treatment (p<0.05). CONCLUSION: Isotretinoin therapy improved the quality of life of patients suffering from acne, but depression was accentuated in the patients to some extent.
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spelling pubmed-43618272015-03-19 The Effect of Isotretinoin (Roaccutane) Therapy on Depression and Quality of Life of Patients with Severe Acne Fakour, Youssef Noormohammadpour, Pedram Ameri, Hamed Ehsani, Amir Houshang Mokhtari, Leila Khosrovanmehr, Najmeh Hoseini nezhad, Seyedeh Zahra Iran J Psychiatry Medical Sciences OBJECTIVE: Acne is the most common skin disease and isotretinoin is the most powerful drug among the various drugs used for its treatment, but it has some adverse effects. The aim of this study was to evaluate the effect of isotretinoin on depression and quality of life of a group of patients undergoing isotretinoin therapy before and after the treatment course. METHODS: In this prospective study, 98 patients with severe acne were enrolled consecutively and underwent isotretinoin therapy receiving 0.5 mg/kg/d of isotretinoin for 16 weeks. Isotretinoin effects on quality of life and depression were evaluated using Dermatology Life Quality Index (DLQI) and Beck Depression Inventory (BDI) questionnaires, respectively. RESULTS: In this study, 98 patients suffering from severe acne (38 males and 60 females) were enrolled. Treatment of acne was associated with improvement of quality of life scores in both male and female patients (p = 0.001). Considering the cutoff value of 13 for mild depressive mood in the BDI score, in total, 48 (49%) of the enrolled patients (21 males and 33 females) had a mild depressive mood before the commencement of the treatment in this study. The analysis of before and after treatment BDI scores showed that the number of patients and also the mean score of BDI were increased in both male and female patients after the treatment (p<0.05). CONCLUSION: Isotretinoin therapy improved the quality of life of patients suffering from acne, but depression was accentuated in the patients to some extent. Tehran University of Medical Sciences 2014-10 /pmc/articles/PMC4361827/ /pubmed/25792992 Text en Copyright: © Iranian Journal of Psychiatry & Tehran University of Medical Sciences This work is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly.
spellingShingle Medical Sciences
Fakour, Youssef
Noormohammadpour, Pedram
Ameri, Hamed
Ehsani, Amir Houshang
Mokhtari, Leila
Khosrovanmehr, Najmeh
Hoseini nezhad, Seyedeh Zahra
The Effect of Isotretinoin (Roaccutane) Therapy on Depression and Quality of Life of Patients with Severe Acne
title The Effect of Isotretinoin (Roaccutane) Therapy on Depression and Quality of Life of Patients with Severe Acne
title_full The Effect of Isotretinoin (Roaccutane) Therapy on Depression and Quality of Life of Patients with Severe Acne
title_fullStr The Effect of Isotretinoin (Roaccutane) Therapy on Depression and Quality of Life of Patients with Severe Acne
title_full_unstemmed The Effect of Isotretinoin (Roaccutane) Therapy on Depression and Quality of Life of Patients with Severe Acne
title_short The Effect of Isotretinoin (Roaccutane) Therapy on Depression and Quality of Life of Patients with Severe Acne
title_sort effect of isotretinoin (roaccutane) therapy on depression and quality of life of patients with severe acne
topic Medical Sciences
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4361827/
https://www.ncbi.nlm.nih.gov/pubmed/25792992
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