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A retrospective analysis of negative diffusion-weighted image results in patients with acute cerebral infarction

We aimed to investigate the clinicoradiologic determinants of negative diffusion-weighted image (DWI) results in patients with acute cerebral infarction (ACI). The medical records were reviewed of ACI patients. Patients were divided to the DWI positive and negative group. Positive DWI was used as in...

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Autores principales: Zuo, Lian, Zhang, Yue, Xu, Xiahong, Li, Ying, Bao, Huan, Hao, Junjie, Wang, Xin, Li, Gang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4361873/
https://www.ncbi.nlm.nih.gov/pubmed/25777182
http://dx.doi.org/10.1038/srep08910
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author Zuo, Lian
Zhang, Yue
Xu, Xiahong
Li, Ying
Bao, Huan
Hao, Junjie
Wang, Xin
Li, Gang
author_facet Zuo, Lian
Zhang, Yue
Xu, Xiahong
Li, Ying
Bao, Huan
Hao, Junjie
Wang, Xin
Li, Gang
author_sort Zuo, Lian
collection PubMed
description We aimed to investigate the clinicoradiologic determinants of negative diffusion-weighted image (DWI) results in patients with acute cerebral infarction (ACI). The medical records were reviewed of ACI patients. Patients were divided to the DWI positive and negative group. Positive DWI was used as independent variable and patients' clinicoradiologic factors were used as co-variables for multivariate logistic regression analysis. 349 patients received initial cerebral MRI within 72 hours of admission. Lacunar infarction was most common (42.1%) followed by posterior circulation infarction (30.1%) and partial anterior circulation infarction (18.1%). The majority of the patients (72.2%) had an NIHSS score of less than 5 at admission. 316 patients (90.54%) were positive on initial DWI. Patients with smoking, initial SBP ≥ 140 or DBP ≥ 90 mmHg, initial fasting plasma glucose (FPG) ≥7.0 mmol/L, initial MRI from onset of disease >1 d and anterior circulation infarction were liable to show positive DWI. Furthermore, DWI negative patients had significantly lower NIHSS scores (IQR 0,1,2) than DWI positive patients (IQR 1,2,4) (P = 0.000) at two weeks post onset of acute cerebral infarction. In conclusion, multiple clinicoradiologic factors are associated with negative and positive DWI and further delineation of these factors is required in future prospective studies.
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spelling pubmed-43618732015-03-19 A retrospective analysis of negative diffusion-weighted image results in patients with acute cerebral infarction Zuo, Lian Zhang, Yue Xu, Xiahong Li, Ying Bao, Huan Hao, Junjie Wang, Xin Li, Gang Sci Rep Article We aimed to investigate the clinicoradiologic determinants of negative diffusion-weighted image (DWI) results in patients with acute cerebral infarction (ACI). The medical records were reviewed of ACI patients. Patients were divided to the DWI positive and negative group. Positive DWI was used as independent variable and patients' clinicoradiologic factors were used as co-variables for multivariate logistic regression analysis. 349 patients received initial cerebral MRI within 72 hours of admission. Lacunar infarction was most common (42.1%) followed by posterior circulation infarction (30.1%) and partial anterior circulation infarction (18.1%). The majority of the patients (72.2%) had an NIHSS score of less than 5 at admission. 316 patients (90.54%) were positive on initial DWI. Patients with smoking, initial SBP ≥ 140 or DBP ≥ 90 mmHg, initial fasting plasma glucose (FPG) ≥7.0 mmol/L, initial MRI from onset of disease >1 d and anterior circulation infarction were liable to show positive DWI. Furthermore, DWI negative patients had significantly lower NIHSS scores (IQR 0,1,2) than DWI positive patients (IQR 1,2,4) (P = 0.000) at two weeks post onset of acute cerebral infarction. In conclusion, multiple clinicoradiologic factors are associated with negative and positive DWI and further delineation of these factors is required in future prospective studies. Nature Publishing Group 2015-03-17 /pmc/articles/PMC4361873/ /pubmed/25777182 http://dx.doi.org/10.1038/srep08910 Text en Copyright © 2015, Macmillan Publishers Limited. All rights reserved http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder in order to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Zuo, Lian
Zhang, Yue
Xu, Xiahong
Li, Ying
Bao, Huan
Hao, Junjie
Wang, Xin
Li, Gang
A retrospective analysis of negative diffusion-weighted image results in patients with acute cerebral infarction
title A retrospective analysis of negative diffusion-weighted image results in patients with acute cerebral infarction
title_full A retrospective analysis of negative diffusion-weighted image results in patients with acute cerebral infarction
title_fullStr A retrospective analysis of negative diffusion-weighted image results in patients with acute cerebral infarction
title_full_unstemmed A retrospective analysis of negative diffusion-weighted image results in patients with acute cerebral infarction
title_short A retrospective analysis of negative diffusion-weighted image results in patients with acute cerebral infarction
title_sort retrospective analysis of negative diffusion-weighted image results in patients with acute cerebral infarction
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4361873/
https://www.ncbi.nlm.nih.gov/pubmed/25777182
http://dx.doi.org/10.1038/srep08910
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