Cargando…

Structure of the AcrAB-TolC multidrug efflux pump

The capacity of numerous bacterial species to tolerate antibiotics and other toxic compounds arises in part from the activity of energy-dependent transporters. In Gram-negative bacteria, many of these transporters form multicomponent ‘pumps’ that span both inner and outer membranes and are driven en...

Descripción completa

Detalles Bibliográficos
Autores principales:	Du, Dijun, Wang, Zhao, James, Nathan R., Voss, Jarrod E., Klimont, Ewa, Ohene-Agyei, Thelma, Venter, Henrietta, Chiu, Wah, Luisi, Ben F.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4361902/ https://www.ncbi.nlm.nih.gov/pubmed/24747401 http://dx.doi.org/10.1038/nature13205

Ejemplares similares

An allosteric transport mechanism for the AcrAB-TolC multidrug efflux pump
por: Wang, Zhao, et al.
Publicado: (2017)

In situ structure and assembly of the multidrug efflux pump AcrAB-TolC
por: Shi, Xiaodong, et al.
Publicado: (2019)

Pimozide Inhibits the AcrAB-TolC Efflux Pump in Escherichia coli
por: Bohnert, Jürgen A, et al.
Publicado: (2013)

A Model for Allosteric Communication in Drug Transport by the AcrAB-TolC Tripartite Efflux Pump
por: Webber, Anya, et al.
Publicado: (2022)

Mutations in the TolC Periplasmic Domain Affect Substrate Specificity of the AcrAB-TolC Pump
por: Marshall, Robert L., et al.
Publicado: (2020)

Expression of the AcrAB Components of the AcrAB-TolC Multidrug Efflux Pump of Yersinia enterocolitica Is Subject to Dual Regulation by OmpR
por: Raczkowska, Adrianna, et al.
Publicado: (2015)

Antibacterial Efficacy of Polysaccharide Capped Silver Nanoparticles Is Not Compromised by AcrAB-TolC Efflux Pump
por: Mishra, Mitali, et al.
Publicado: (2018)

Contribution of the efflux pump AcrAB-TolC to the tolerance of chlorhexidine and other biocides in Klebsiella spp.
por: Wand, Matthew E., et al.
Publicado: (2022)

RamA, which controls expression of the MDR efflux pump AcrAB-TolC, is regulated by the Lon protease
por: Ricci, Vito, et al.
Publicado: (2014)

AcrAB-TolC efflux pump system plays a role in carbapenem non-susceptibility in Escherichia coli
por: Chetri, Shiela, et al.
Publicado: (2019)

Sodium Malonate Inhibits the AcrAB-TolC Multidrug Efflux Pump of Escherichia coli and Increases Antibiotic Efficacy
por: Cauilan, Allea, et al.
Publicado: (2022)

AcrAB−TolC, a major efflux pump in Gram negative bacteria: toward understanding its operation mechanism
por: Jang, Soojin
Publicado: (2023)

Genetic Variability of the AcrAB-TolC Multidrug Efflux Pump Underlies SkQ1 Resistance in Gram-Negative Bacteria
por: Nazarov, P. A., et al.
Publicado: (2019)

Time dependent asymptotic analysis of the gene regulatory network of the AcrAB-TolC efflux pump system in gram-negative bacteria
por: Youlden, George H., et al.
Publicado: (2021)

Inhibition of AcrAB-TolC enhances antimicrobial activity of phytochemicals in Pectobacterium brasiliense
por: Pun, Manoj, et al.
Publicado: (2023)

Study on the association between drug-resistance and gene mutations of the active efflux pump acrAB-tolC gene and its regulatory genes
por: Ma, Quan-Ping, et al.
Publicado: (2018)

Mapping the Role of AcrAB-TolC Efflux Pumps in the Evolution of Antibiotic Resistance Reveals Near-MIC Treatments Facilitate Resistance Acquisition
por: Langevin, Ariel M., et al.
Publicado: (2020)

Insight into the AcrAB-TolC Complex Assembly Process Learned from Competition Studies
por: Rajapaksha, Prasangi, et al.
Publicado: (2021)

Loss of the Periplasmic Chaperone Skp and Mutations in the Efflux Pump AcrAB-TolC Play a Role in Acquired Resistance to Antimicrobial Peptides in Salmonella typhimurium
por: Kapach, Gal, et al.
Publicado: (2020)

Screening and Characterization of Streptomyces spp. Isolated from Three Moroccan Ecosystems Producing a Potential Inhibitor of the Drug Efflux Pump AcrAB-TolC
por: Azmani, Asma, et al.
Publicado: (2022)

Structure of the MacAB-TolC ABC-type tripartite multidrug efflux pump
por: Fitzpatrick, Anthony W.P., et al.
Publicado: (2017)

Identification of AcrAB-TolC Efflux Pump Genes and Detection of Mutation in Efflux Repressor AcrR from Omeprazole Responsive Multidrug-Resistant Escherichia coli Isolates Causing Urinary Tract Infections
por: Chowdhury, Nandan, et al.
Publicado: (2019)

Drug Efflux Pump Inhibitors: A Promising Approach to Counter Multidrug Resistance in Gram-Negative Pathogens by Targeting AcrB Protein from AcrAB-TolC Multidrug Efflux Pump from Escherichia coli
por: Alenazy, Rawaf
Publicado: (2022)

Galactose-Clicked Curcumin-Mediated Reversal of Meropenem Resistance among Klebsiella pneumoniae by Targeting Its Carbapenemases and the AcrAB-TolC Efflux System
por: Yadav, Shivangi, et al.
Publicado: (2021)

Isolation of Escherichia coli Strains with AcrAB–TolC Efflux Pump-Associated Intermediate Interpretation or Resistance to Fluoroquinolone, Chloramphenicol and Aminopenicillin from Dogs Admitted to a University Veterinary Hospital
por: SATO, Toyotaka, et al.
Publicado: (2014)

Expression of the marA, soxS, acrB and ramA genes related to the AcrAB/TolC efflux pump in Salmonella enterica strains with and without quinolone resistance-determining regions gyrA gene mutations
por: Ferrari, Rafaela Gomes, et al.
Publicado: (2013)

Protoporphyrin (PPIX) efflux by the MacAB-TolC pump in Escherichia coli
por: Turlin, Evelyne, et al.
Publicado: (2014)

Role of the MDR Efflux Pump AcrAB in Epithelial Cell Invasion by Shigella flexneri
por: Coluccia, Marco, et al.
Publicado: (2023)

Biocide Selective TolC-Independent Efflux Pumps in Enterobacteriaceae
por: Slipski, Carmine J., et al.
Publicado: (2017)

Local Repressor AcrR Regulates AcrAB Efflux Pump Required for Biofilm Formation and Virulence in Acinetobacter nosocomialis
por: Subhadra, Bindu, et al.
Publicado: (2018)

Contribution of AcrAB efflux pump to ciprofloxacin resistance in Klebsiella pneumoniae isolated from burn patients
por: Pakzad, Iraj, et al.
Publicado: (2013)

Transcriptional Modulation of Penicillin-Binding Protein 1b, Outer Membrane Protein P2 and Efflux Pump (AcrAB-TolC) during Heat Stress Is Correlated to Enhanced Bactericidal Action of Imipenem on Non-typeable Haemophilus influenzae
por: Cherkaoui, Abdessalam, et al.
Publicado: (2018)

A Requirement of TolC and MDR Efflux Pumps for Acid Adaptation and GadAB Induction in Escherichia coli
por: Deininger, Kari N. W., et al.
Publicado: (2011)

Genetic inactivation of acrAB or inhibition of efflux induces expression of ramA
por: Lawler, A. J., et al.
Publicado: (2013)

Phytochemicals increase the antibacterial activity of antibiotics by acting on a drug efflux pump
por: Ohene-Agyei, Thelma, et al.
Publicado: (2014)

Genetic variation in the MacAB-TolC efflux pump influences pathogenesis of invasive Salmonella isolates from Africa
por: Honeycutt, Jared D., et al.
Publicado: (2020)

AcrAB Multidrug Efflux Pump Regulation in Salmonella enterica serovar Typhimurium by RamA in Response to Environmental Signals
por: Nikaido, Eiji, et al.
Publicado: (2008)

AcrAB efflux pump impacts on the survival of adherent-invasive Escherichia coli strain LF82 inside macrophages
por: Fanelli, Giulia, et al.
Publicado: (2023)

RND-type drug eﬄux pumps from Gram-negative bacteria: molecular mechanism and inhibition
por: Venter, Henrietta, et al.
Publicado: (2015)

Efflux Pump AcrAB Confers Decreased Susceptibility to Piperacillin–Tazobactam and Ceftolozane–Tazobactam in Tigecycline-Non-Susceptible Klebsiella pneumoniae
por: Li, Junjie, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_1p9enqc01kqs6sf53l4to68s5v