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Effects of Pioglitazone or Exercise in Older Adults with Mild Cognitive Impairment and Insulin Resistance: A Pilot Study

AIMS: To examine the effects of pioglitazone or endurance exercise training on cognitive function in older adults with mild cognitive impairment (MCI) and insulin resistance. METHODS: Seventy-eight adults (mean age ± SD: 65 ± 7 years) with central obesity and MCI were randomized to 6 months of endur...

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Detalles Bibliográficos
Autores principales: Hildreth, Kerry L., Van Pelt, Rachael E., Moreau, Kerrie L., Grigsby, Jim, Hoth, Karin F., Pelak, Victoria, Anderson, C. Alan, Parnes, Bennett, Kittelson, John, Wolfe, Pamela, Nakamura, Tammie, Linnebur, Sunny A., Trujillo, Jennifer M., Aquilante, Christina L., Schwartz, Robert S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4361908/
https://www.ncbi.nlm.nih.gov/pubmed/25852732
http://dx.doi.org/10.1159/000371509
Descripción
Sumario:AIMS: To examine the effects of pioglitazone or endurance exercise training on cognitive function in older adults with mild cognitive impairment (MCI) and insulin resistance. METHODS: Seventy-eight adults (mean age ± SD: 65 ± 7 years) with central obesity and MCI were randomized to 6 months of endurance exercise, pioglitazone or control. RESULTS: Sixty-six participants completed the study. Exercise training did not significantly increase peak oxygen uptake compared to control (p = 0.12). Compared to control, insulin resistance improved in the pioglitazone group (p = 0.002) but not in the exercise group (p = 0.25). There was no measureable effect of pioglitazone or exercise on cognitive performance compared to control. CONCLUSION: In this pilot study, pioglitazone improved insulin resistance but not cognitive performance in older adults with MCI and insulin resistance.