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Effects of Pioglitazone or Exercise in Older Adults with Mild Cognitive Impairment and Insulin Resistance: A Pilot Study
AIMS: To examine the effects of pioglitazone or endurance exercise training on cognitive function in older adults with mild cognitive impairment (MCI) and insulin resistance. METHODS: Seventy-eight adults (mean age ± SD: 65 ± 7 years) with central obesity and MCI were randomized to 6 months of endur...
| Autores principales: | , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
S. Karger AG
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4361908/ https://www.ncbi.nlm.nih.gov/pubmed/25852732 http://dx.doi.org/10.1159/000371509 |
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| author | Hildreth, Kerry L. Van Pelt, Rachael E. Moreau, Kerrie L. Grigsby, Jim Hoth, Karin F. Pelak, Victoria Anderson, C. Alan Parnes, Bennett Kittelson, John Wolfe, Pamela Nakamura, Tammie Linnebur, Sunny A. Trujillo, Jennifer M. Aquilante, Christina L. Schwartz, Robert S. |
| author_facet | Hildreth, Kerry L. Van Pelt, Rachael E. Moreau, Kerrie L. Grigsby, Jim Hoth, Karin F. Pelak, Victoria Anderson, C. Alan Parnes, Bennett Kittelson, John Wolfe, Pamela Nakamura, Tammie Linnebur, Sunny A. Trujillo, Jennifer M. Aquilante, Christina L. Schwartz, Robert S. |
| author_sort | Hildreth, Kerry L. |
| collection | PubMed |
| description | AIMS: To examine the effects of pioglitazone or endurance exercise training on cognitive function in older adults with mild cognitive impairment (MCI) and insulin resistance. METHODS: Seventy-eight adults (mean age ± SD: 65 ± 7 years) with central obesity and MCI were randomized to 6 months of endurance exercise, pioglitazone or control. RESULTS: Sixty-six participants completed the study. Exercise training did not significantly increase peak oxygen uptake compared to control (p = 0.12). Compared to control, insulin resistance improved in the pioglitazone group (p = 0.002) but not in the exercise group (p = 0.25). There was no measureable effect of pioglitazone or exercise on cognitive performance compared to control. CONCLUSION: In this pilot study, pioglitazone improved insulin resistance but not cognitive performance in older adults with MCI and insulin resistance. |
| format | Online Article Text |
| id | pubmed-4361908 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2015 |
| publisher | S. Karger AG |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-43619082015-04-07 Effects of Pioglitazone or Exercise in Older Adults with Mild Cognitive Impairment and Insulin Resistance: A Pilot Study Hildreth, Kerry L. Van Pelt, Rachael E. Moreau, Kerrie L. Grigsby, Jim Hoth, Karin F. Pelak, Victoria Anderson, C. Alan Parnes, Bennett Kittelson, John Wolfe, Pamela Nakamura, Tammie Linnebur, Sunny A. Trujillo, Jennifer M. Aquilante, Christina L. Schwartz, Robert S. Dement Geriatr Cogn Dis Extra Original Research Article AIMS: To examine the effects of pioglitazone or endurance exercise training on cognitive function in older adults with mild cognitive impairment (MCI) and insulin resistance. METHODS: Seventy-eight adults (mean age ± SD: 65 ± 7 years) with central obesity and MCI were randomized to 6 months of endurance exercise, pioglitazone or control. RESULTS: Sixty-six participants completed the study. Exercise training did not significantly increase peak oxygen uptake compared to control (p = 0.12). Compared to control, insulin resistance improved in the pioglitazone group (p = 0.002) but not in the exercise group (p = 0.25). There was no measureable effect of pioglitazone or exercise on cognitive performance compared to control. CONCLUSION: In this pilot study, pioglitazone improved insulin resistance but not cognitive performance in older adults with MCI and insulin resistance. S. Karger AG 2015-02-20 /pmc/articles/PMC4361908/ /pubmed/25852732 http://dx.doi.org/10.1159/000371509 Text en Copyright © 2015 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article licensed under the terms of the Creative Commons Attribution-NonCommercial 3.0 Unported license (CC BY-NC) (www.karger.com/OA-license), applicable to the online version of the article only. Users may download, print and share this work on the Internet for noncommercial purposes only, provided the original work is properly cited, and a link to the original work on http://www.karger.com and the terms of this license are included in any shared versions. |
| spellingShingle | Original Research Article Hildreth, Kerry L. Van Pelt, Rachael E. Moreau, Kerrie L. Grigsby, Jim Hoth, Karin F. Pelak, Victoria Anderson, C. Alan Parnes, Bennett Kittelson, John Wolfe, Pamela Nakamura, Tammie Linnebur, Sunny A. Trujillo, Jennifer M. Aquilante, Christina L. Schwartz, Robert S. Effects of Pioglitazone or Exercise in Older Adults with Mild Cognitive Impairment and Insulin Resistance: A Pilot Study |
| title | Effects of Pioglitazone or Exercise in Older Adults with Mild Cognitive Impairment and Insulin Resistance: A Pilot Study |
| title_full | Effects of Pioglitazone or Exercise in Older Adults with Mild Cognitive Impairment and Insulin Resistance: A Pilot Study |
| title_fullStr | Effects of Pioglitazone or Exercise in Older Adults with Mild Cognitive Impairment and Insulin Resistance: A Pilot Study |
| title_full_unstemmed | Effects of Pioglitazone or Exercise in Older Adults with Mild Cognitive Impairment and Insulin Resistance: A Pilot Study |
| title_short | Effects of Pioglitazone or Exercise in Older Adults with Mild Cognitive Impairment and Insulin Resistance: A Pilot Study |
| title_sort | effects of pioglitazone or exercise in older adults with mild cognitive impairment and insulin resistance: a pilot study |
| topic | Original Research Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4361908/ https://www.ncbi.nlm.nih.gov/pubmed/25852732 http://dx.doi.org/10.1159/000371509 |
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