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Pentacam topographic changes after collagen cross-linking in patients with keratoconus

BACKGROUND: Corneal cross-linking (CXL) with riboflavin and ultra-violet A is less invasive in comparison with other procedures such as penetrating keratoplasty. Hence, we planned this study to evaluate the efficacy of CXL in disease progression and to compare keratoconus indices before and 1 year a...

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Autores principales: Razmjoo, Hassan, Rahgozar, Aminhossein, Shirani, Kiana, Abtahi, Seyed-Hossein
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4361965/
https://www.ncbi.nlm.nih.gov/pubmed/25802831
http://dx.doi.org/10.4103/2277-9175.151886
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author Razmjoo, Hassan
Rahgozar, Aminhossein
Shirani, Kiana
Abtahi, Seyed-Hossein
author_facet Razmjoo, Hassan
Rahgozar, Aminhossein
Shirani, Kiana
Abtahi, Seyed-Hossein
author_sort Razmjoo, Hassan
collection PubMed
description BACKGROUND: Corneal cross-linking (CXL) with riboflavin and ultra-violet A is less invasive in comparison with other procedures such as penetrating keratoplasty. Hence, we planned this study to evaluate the efficacy of CXL in disease progression and to compare keratoconus indices before and 1 year after cross-linking by Pentacam. MATERIALS AND METHODS: In this prospective clinical trial, we enrolled 37 eyes of 37 patients suffering from keratoconus who were candidates for CXL. All eyes were examined before and one 1 year after surgery with a slit lamp and Pentacam for corneal topography. To compare the mean of each Pentacam parameter and index before and 1 year after the surgery, we used paired t-test. RESULTS: There were 23 males and 14 females. The mean age was 21.5 years 18-30 years). At the 12(th) month examination, the corneal thickness had decreased (P = 0.0068) and the Index of Height Decentration (IHD) had increased (P = 0.016). There were no statistically significant differences in other indices and parameters 1 year after CXL. CONCLUSION: Most of the parameters and indices had not changed during 1 year after CXL. The procedure seems to be effective in stopping the disease progression at least for 12 months after surgery.
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spelling pubmed-43619652015-03-23 Pentacam topographic changes after collagen cross-linking in patients with keratoconus Razmjoo, Hassan Rahgozar, Aminhossein Shirani, Kiana Abtahi, Seyed-Hossein Adv Biomed Res Original Article BACKGROUND: Corneal cross-linking (CXL) with riboflavin and ultra-violet A is less invasive in comparison with other procedures such as penetrating keratoplasty. Hence, we planned this study to evaluate the efficacy of CXL in disease progression and to compare keratoconus indices before and 1 year after cross-linking by Pentacam. MATERIALS AND METHODS: In this prospective clinical trial, we enrolled 37 eyes of 37 patients suffering from keratoconus who were candidates for CXL. All eyes were examined before and one 1 year after surgery with a slit lamp and Pentacam for corneal topography. To compare the mean of each Pentacam parameter and index before and 1 year after the surgery, we used paired t-test. RESULTS: There were 23 males and 14 females. The mean age was 21.5 years 18-30 years). At the 12(th) month examination, the corneal thickness had decreased (P = 0.0068) and the Index of Height Decentration (IHD) had increased (P = 0.016). There were no statistically significant differences in other indices and parameters 1 year after CXL. CONCLUSION: Most of the parameters and indices had not changed during 1 year after CXL. The procedure seems to be effective in stopping the disease progression at least for 12 months after surgery. Medknow Publications & Media Pvt Ltd 2015-02-23 /pmc/articles/PMC4361965/ /pubmed/25802831 http://dx.doi.org/10.4103/2277-9175.151886 Text en Copyright: © 2015 Razmjoo. http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Original Article
Razmjoo, Hassan
Rahgozar, Aminhossein
Shirani, Kiana
Abtahi, Seyed-Hossein
Pentacam topographic changes after collagen cross-linking in patients with keratoconus
title Pentacam topographic changes after collagen cross-linking in patients with keratoconus
title_full Pentacam topographic changes after collagen cross-linking in patients with keratoconus
title_fullStr Pentacam topographic changes after collagen cross-linking in patients with keratoconus
title_full_unstemmed Pentacam topographic changes after collagen cross-linking in patients with keratoconus
title_short Pentacam topographic changes after collagen cross-linking in patients with keratoconus
title_sort pentacam topographic changes after collagen cross-linking in patients with keratoconus
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4361965/
https://www.ncbi.nlm.nih.gov/pubmed/25802831
http://dx.doi.org/10.4103/2277-9175.151886
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