Cargando…

Novel insights into mechanisms for Pak1-mediated regulation of cardiac Ca(2+) homeostasis

A series of recent studies report novel roles for Pak1, a key member of the highly conserved family of serine-threonine protein kinases regulated by Ras-related small G-proteins, Cdc42/Rac1, in cardiac physiology and cardioprotection. Previous studies had identified Pak1 in the regulation of hypertr...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Yanwen, Tsui, Hoyee, Bolton, Emma L., Wang, Xin, Huang, Christopher L.-H., Solaro, R. John, Ke, Yunbo, Lei, Ming
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2015
Materias:	Physiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4362298/ https://www.ncbi.nlm.nih.gov/pubmed/25852566 http://dx.doi.org/10.3389/fphys.2015.00076

Ejemplares similares

Regulation of Ca(2+) transient by PP2A in normal and failing heart
por: Lei, Ming, et al.
Publicado: (2015)

Novel roles of PAK1 in the heart
por: Ke, Yunbo, et al.
Publicado: (2012)

Editorial: Ca(2+) Signaling and Heart Rhythm
por: Huang, Christopher L.-H., et al.
Publicado: (2016)

Assessing the cardiac autonomic response to bicycle exercise in Olympic athletes with different loads of endurance training: new insights from statistical indicators based on multilevel exploratory factor analysis
por: Solaro, Nadia, et al.
Publicado: (2023)

Abnormal Ca(2+) homeostasis, atrial arrhythmogenesis, and sinus node dysfunction in murine hearts modeling RyR2 modification
por: Zhang, Yanmin, et al.
Publicado: (2013)

Urocortin-2 Prevents Dysregulation of Ca(2+) Homeostasis and Improves Early Cardiac Remodeling After Ischemia and Reperfusion
por: Domínguez-Rodríguez, Alejandro, et al.
Publicado: (2018)

Altered Cardiac Autonomic Regulation in Overweight and Obese Subjects: The Role of Age-and-Gender-Adjusted Statistical Indicators of Heart Rate Variability and Cardiac Baroreflex
por: Solaro, Nadia, et al.
Publicado: (2021)

The curious role of sarcomeric proteins in control of diverse processes in cardiac myocytes
por: Solaro, R. John, et al.
Publicado: (2010)

LETM1-Mediated K(+) and Na(+) Homeostasis Regulates Mitochondrial Ca(2+) Efflux
por: Austin, Shane, et al.
Publicado: (2017)

Cardiac Baroreflex, HRV, and Statistics: An Interdisciplinary Approach in Hypertension
por: Solaro, Nadia, et al.
Publicado: (2019)

Endosome-based protein trafficking and Ca(2+) homeostasis in the heart
por: Curran, Jerry, et al.
Publicado: (2015)

Unique catalytic activities and scaffolding of p21 activated kinase-1 in cardiovascular signaling
por: Ke, Yunbo, et al.
Publicado: (2013)

Enhancing Autophagy Diminishes Aberrant Ca(2+) Homeostasis and Arrhythmogenesis in Aging Rabbit Hearts
por: Murphy, Kevin R., et al.
Publicado: (2019)

Dysferlin at transverse tubules regulates Ca(2+) homeostasis in skeletal muscle
por: Kerr, Jaclyn P., et al.
Publicado: (2014)

Use of a decoy peptide to purify p21 activated kinase-1 in cardiac muscle and identification of ceramide-related activation
por: Ke, Yunbo, et al.
Publicado: (2008)

Inhibition of Angiotensin II-Induced Cardiac Hypertrophy and Associated Ventricular Arrhythmias by a p21 Activated Kinase 1 Bioactive Peptide
por: Wang, Rui, et al.
Publicado: (2014)

Novel control of cardiac myofilament response to calcium by S-glutathionylation at specific sites of myosin binding protein C
por: Patel, Bindiya G., et al.
Publicado: (2013)

Altered Ca(2+) and Na(+) Homeostasis in Human Hypertrophic Cardiomyopathy: Implications for Arrhythmogenesis
por: Coppini, Raffaele, et al.
Publicado: (2018)

Synchronization of Intracellular Ca(2+) Release in Multicellular Cardiac Preparations
por: Slabaugh, Jessica L., et al.
Publicado: (2018)

Total Matrix Ca(2+) Modulates Ca(2+) Efflux via the Ca(2+)/H(+) Exchanger in Cardiac Mitochondria
por: Natarajan, Gayathri K., et al.
Publicado: (2020)

Novel bradykinin signaling in adult rat cardiac myocytes through activation of p21-activated kinase
por: Ke, Yunbo, et al.
Publicado: (2010)

Activation of Pak1/Akt/eNOS signaling following sphingosine-1-phosphate release as part of a mechanism protecting cardiomyocytes against ischemic cell injury
por: Egom, Emmanuel Eroume A., et al.
Publicado: (2011)

Plasma membrane Ca(2+)‐ATPase 1 is required for maintaining atrial Ca(2+) homeostasis and electrophysiological stability in the mouse
por: Wang, Yanwen, et al.
Publicado: (2017)

Functional Deficits in Pak5, Pak6 and Pak5/Pak6 Knockout Mice
por: Furnari, Melody A., et al.
Publicado: (2013)

Proarrhythmic Remodeling of Calcium Homeostasis in Cardiac Disease; Implications for Diabetes and Obesity
por: Hamilton, Shanna, et al.
Publicado: (2018)

Visualizing Cyclic Adenosine Monophosphate in Cardiac Microdomains Involved in Ion Homeostasis
por: Dikolayev, Vladimir, et al.
Publicado: (2019)

The other side of cardiac Ca(2+) signaling: transcriptional control
por: Domínguez-Rodríguez, Alejandro, et al.
Publicado: (2012)

B-arrestin-2 Signaling Is Important to Preserve Cardiac Function During Aging
por: Capote, Andrielle E., et al.
Publicado: (2021)

Come Together: Protein Assemblies, Aggregates and the Sarcostat at the Heart of Cardiac Myocyte Homeostasis
por: Islam, Moydul, et al.
Publicado: (2020)

Effects of Different Exercise Training Protocols on Gene Expression of Rac1 and PAK1 in Healthy Rat Fast- and Slow-Type Muscles
por: Laine, Saara, et al.
Publicado: (2020)

Functional insights into modulation of BK(Ca) channel activity to alter myometrial contractility
por: Lorca, Ramón A., et al.
Publicado: (2014)

Antagonizing Sec62 function in intracellular Ca(2+) homeostasis represents a novel therapeutic strategy for head and neck cancer
por: Körner, Sandrina, et al.
Publicado: (2022)

Role of NKCC1 Activity in Glioma K(+) Homeostasis and Cell Growth: New Insights With the Bumetanide-Derivative STS66
por: Luo, Lanxin, et al.
Publicado: (2020)

Autonomic Differentiation Map: A Novel Statistical Tool for Interpretation of Heart Rate Variability
por: Lucini, Daniela, et al.
Publicado: (2018)

Unbalance Between Sarcoplasmic Reticulum Ca(2 +) Uptake and Release: A First Step Toward Ca(2 +) Triggered Arrhythmias and Cardiac Damage
por: Federico, Marilén, et al.
Publicado: (2020)

A Temporal Examination of Cytoplasmic Ca(2 +) Levels, Sarcoplasmic Reticulum Ca(2 +) Levels, and Ca(2 +) -Handling-Related Proteins in Different Skeletal Muscles of Hibernating Daurian Ground Squirrels
por: Wang, Zhe, et al.
Publicado: (2020)

Human Cardiac (31)P-MR Spectroscopy at 3 Tesla Cannot Detect Failing Myocardial Energy Homeostasis during Exercise
por: Bakermans, Adrianus J., et al.
Publicado: (2017)

Genetic background influences adaptation to cardiac hypertrophy and Ca(2+) handling gene expression
por: Waters, Steve B., et al.
Publicado: (2013)

The Interplay of Rogue and Clustered Ryanodine Receptors Regulates Ca(2+) Waves in Cardiac Myocytes
por: Chen, Xudong, et al.
Publicado: (2018)

Schizosaccharomyces pombe Pak-related protein, Pak1p/Orb2p, phosphorylates myosin regulatory light chain to inhibit cytokinesis
por: Loo, Tsui-Han, et al.
Publicado: (2008)

Cannot write session to /tmp/vufind_sessions/sess_b58dp3pdrdp347589hnt1fuhhf