Localization of mutant ubiquitin in the brain of a transgenic mouse line with proteasomal inhibition and its validation at specific sites in Alzheimer's disease

Loss of protein quality control by the ubiquitin-proteasome system (UPS) during aging is one of the processes putatively contributing to cellular stress and Alzheimer's disease (AD) pathogenesis. Recently, pooled Genome Wide Association Studies (GWAS), pathway analysis and proteomics identified...

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Detalles Bibliográficos
Autores principales: Gentier, Romina J. G., Verheijen, Bert M., Zamboni, Margherita, Stroeken, Maartje M. A., Hermes, Denise J. H. P., Küsters, Benno, Steinbusch, Harry W. M., Hopkins, David A., Van Leeuwen, Fred W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4362318/
https://www.ncbi.nlm.nih.gov/pubmed/25852488
http://dx.doi.org/10.3389/fnana.2015.00026

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