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AAV8-mediated Sirt1 gene transfer to the liver prevents high carbohydrate diet-induced nonalcoholic fatty liver disease

Nonalcoholic fatty liver disease (NAFLD) is the most common hepatic disease worldwide, and evidence suggests that it promotes insulin resistance and type 2 diabetes. Caloric restriction (CR) is the only available strategy for NAFLD treatment. The protein deacetylase Sirtuin1 (SIRT1), which is activa...

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Detalles Bibliográficos
Autores principales:	Vilà, Laia, Elias, Ivet, Roca, Carles, Ribera, Albert, Ferré, Tura, Casellas, Alba, Lage, Ricardo, Franckhauser, Sylvie, Bosch, Fatima
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4362360/ https://www.ncbi.nlm.nih.gov/pubmed/26015978 http://dx.doi.org/10.1038/mtm.2014.39

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