Suppression of leaky expression of adenovirus genes by insertion of microRNA-targeted sequences in the replication-incompetent adenovirus vector genome

Leaky expression of adenovirus (Ad) genes occurs following transduction with a conventional replication-incompetent Ad vector, leading to an induction of cellular immunity against Ad proteins and Ad protein-induced toxicity, especially in the late phase following administration. To suppress the leak...

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Detalles Bibliográficos
Autores principales: Shimizu, Kahori, Sakurai, Fuminori, Tomita, Kyoko, Nagamoto, Yasuhito, Nakamura, Shin-ichiro, Katayama, Kazufumi, Tachibana, Masashi, Kawabata, Kenji, Mizuguchi, Hiroyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4362365/
https://www.ncbi.nlm.nih.gov/pubmed/26015975
http://dx.doi.org/10.1038/mtm.2014.35

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4362365/
https://www.ncbi.nlm.nih.gov/pubmed/26015975
http://dx.doi.org/10.1038/mtm.2014.35

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