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Introduction of a point mutation into an HLA class I single-chain trimer induces enhancement of CTL priming and antitumor immunity

We previously discovered one particular HLA-A*02:01 mutant that enhanced peptide-specific cytotoxic T lymphocyte (CTL) recognition in vitro compared to wild-type HLA-A*02:01. This mutant contains a single amino acid substitution from histidine to leucine at position 74 (H74L) that is located in the...

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Detalles Bibliográficos
Autores principales:	Matsui, Masanori, Kawano, Masaaki, Matsushita, Sho, Akatsuka, Toshitaka
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4362367/ https://www.ncbi.nlm.nih.gov/pubmed/26015969 http://dx.doi.org/10.1038/mtm.2014.27

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