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Somatic CRISPR–Cas9-induced mutations reveal roles of embryonically essential dynein chains in Caenorhabditis elegans cilia

Cilium formation and maintenance require intraflagellar transport (IFT). Although much is known about kinesin-2–driven anterograde IFT, the composition and regulation of retrograde IFT-specific dynein remain elusive. Components of cytoplasmic dynein may participate in IFT; however, their essential r...

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Detalles Bibliográficos
Autores principales: Li, Wenjing, Yi, Peishan, Ou, Guangshuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4362450/
https://www.ncbi.nlm.nih.gov/pubmed/25778918
http://dx.doi.org/10.1083/jcb.201411041