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GGCX and VKORC1 inhibit osteocalcin endocrine functions

Osteocalcin (OCN) is an osteoblast-derived hormone favoring glucose homeostasis, energy expenditure, male fertility, brain development, and cognition. Before being secreted by osteoblasts in the bone extracellular matrix, OCN is γ-carboxylated by the γ-carboxylase (GGCX) on three glutamic acid resid...

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Detalles Bibliográficos
Autores principales:	Ferron, Mathieu, Lacombe, Julie, Germain, Amélie, Oury, Franck, Karsenty, Gérard
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2015
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4362468/ https://www.ncbi.nlm.nih.gov/pubmed/25753038 http://dx.doi.org/10.1083/jcb.201409111

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