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Higher levels of total pepsin and bile acids in the saliva as a possible risk factor for early laryngeal cancer

BACKGROUND: Gastroesophageal reflux is suspected to be an etiological factor in laryngeal and pharyngeal cancer. The aim of this study was to establish, using a non-invasive method, whether laryngopharyngeal reflux (LPR) appears more often in patients with early laryngeal cancer than in a control gr...

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Autores principales: Sereg-Bahar, Maja, Jerin, Ales, Hocevar-Boltezar, Irena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Versita, Warsaw 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4362607/
https://www.ncbi.nlm.nih.gov/pubmed/25810702
http://dx.doi.org/10.2478/raon-2014-0020
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author Sereg-Bahar, Maja
Jerin, Ales
Hocevar-Boltezar, Irena
author_facet Sereg-Bahar, Maja
Jerin, Ales
Hocevar-Boltezar, Irena
author_sort Sereg-Bahar, Maja
collection PubMed
description BACKGROUND: Gastroesophageal reflux is suspected to be an etiological factor in laryngeal and pharyngeal cancer. The aim of this study was to establish, using a non-invasive method, whether laryngopharyngeal reflux (LPR) appears more often in patients with early laryngeal cancer than in a control group. PATIENTS AND METHODS: We compared the pH, the level of bile acids, the total pepsin and the pepsin enzymatic activity in saliva in a group of 30 patients with T1 laryngeal carcinoma and a group of 34 healthy volunteers. RESULTS: The groups differed significantly in terms of levels of total pepsin and bile acids in the saliva sample. Higher levels of total pepsin and bile acids were detected in the group of cancer patients. No significant impact of other known factors influencing laryngeal mucosa (e.g. smoking, alcohol consumption, and the presence of irritating substances in the workplace) on the results of saliva analysis was found. CONCLUSIONS: A higher level of typical components of LPR in the saliva of patients with early laryngeal cancer than in the controls suggests the possibility that LPR, especially biliary reflux, has a role in the development of laryngeal carcinoma.
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spelling pubmed-43626072015-03-25 Higher levels of total pepsin and bile acids in the saliva as a possible risk factor for early laryngeal cancer Sereg-Bahar, Maja Jerin, Ales Hocevar-Boltezar, Irena Radiol Oncol Research Article BACKGROUND: Gastroesophageal reflux is suspected to be an etiological factor in laryngeal and pharyngeal cancer. The aim of this study was to establish, using a non-invasive method, whether laryngopharyngeal reflux (LPR) appears more often in patients with early laryngeal cancer than in a control group. PATIENTS AND METHODS: We compared the pH, the level of bile acids, the total pepsin and the pepsin enzymatic activity in saliva in a group of 30 patients with T1 laryngeal carcinoma and a group of 34 healthy volunteers. RESULTS: The groups differed significantly in terms of levels of total pepsin and bile acids in the saliva sample. Higher levels of total pepsin and bile acids were detected in the group of cancer patients. No significant impact of other known factors influencing laryngeal mucosa (e.g. smoking, alcohol consumption, and the presence of irritating substances in the workplace) on the results of saliva analysis was found. CONCLUSIONS: A higher level of typical components of LPR in the saliva of patients with early laryngeal cancer than in the controls suggests the possibility that LPR, especially biliary reflux, has a role in the development of laryngeal carcinoma. Versita, Warsaw 2015-03-03 /pmc/articles/PMC4362607/ /pubmed/25810702 http://dx.doi.org/10.2478/raon-2014-0020 Text en Copyright © by Association of Radiology & Oncology http://creativecommons.org/licenses/by/3.0 This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Research Article
Sereg-Bahar, Maja
Jerin, Ales
Hocevar-Boltezar, Irena
Higher levels of total pepsin and bile acids in the saliva as a possible risk factor for early laryngeal cancer
title Higher levels of total pepsin and bile acids in the saliva as a possible risk factor for early laryngeal cancer
title_full Higher levels of total pepsin and bile acids in the saliva as a possible risk factor for early laryngeal cancer
title_fullStr Higher levels of total pepsin and bile acids in the saliva as a possible risk factor for early laryngeal cancer
title_full_unstemmed Higher levels of total pepsin and bile acids in the saliva as a possible risk factor for early laryngeal cancer
title_short Higher levels of total pepsin and bile acids in the saliva as a possible risk factor for early laryngeal cancer
title_sort higher levels of total pepsin and bile acids in the saliva as a possible risk factor for early laryngeal cancer
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4362607/
https://www.ncbi.nlm.nih.gov/pubmed/25810702
http://dx.doi.org/10.2478/raon-2014-0020
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