Design, synthesis, and antifungal activities of novel triazole derivatives containing the benzyl group

In previous studies undertaken by our group, a series of 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-substituted-2-propanols (1a–r), which were analogs of fluconazole, was designed and synthesized by click chemistry. In the study reported here, the in vitro antifungal activities of all the t...

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Autores principales: Xu, Kehan, Huang, Lei, Xu, Zheng, Wang, Yanwei, Bai, Guojing, Wu, Qiuye, Wang, Xiaoyan, Yu, Shichong, Jiang, Yuanying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2015
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4362653/
https://www.ncbi.nlm.nih.gov/pubmed/25792806
http://dx.doi.org/10.2147/DDDT.S74989
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author Xu, Kehan
Huang, Lei
Xu, Zheng
Wang, Yanwei
Bai, Guojing
Wu, Qiuye
Wang, Xiaoyan
Yu, Shichong
Jiang, Yuanying
author_facet Xu, Kehan
Huang, Lei
Xu, Zheng
Wang, Yanwei
Bai, Guojing
Wu, Qiuye
Wang, Xiaoyan
Yu, Shichong
Jiang, Yuanying
author_sort Xu, Kehan
collection PubMed
description In previous studies undertaken by our group, a series of 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-substituted-2-propanols (1a–r), which were analogs of fluconazole, was designed and synthesized by click chemistry. In the study reported here, the in vitro antifungal activities of all the target compounds were evaluated against eight human pathogenic fungi. Compounds 1a, 1q, and 1r showed the more antifungal activity than the others.
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spelling pubmed-43626532015-03-19 Design, synthesis, and antifungal activities of novel triazole derivatives containing the benzyl group Xu, Kehan Huang, Lei Xu, Zheng Wang, Yanwei Bai, Guojing Wu, Qiuye Wang, Xiaoyan Yu, Shichong Jiang, Yuanying Drug Des Devel Ther Original Research In previous studies undertaken by our group, a series of 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-substituted-2-propanols (1a–r), which were analogs of fluconazole, was designed and synthesized by click chemistry. In the study reported here, the in vitro antifungal activities of all the target compounds were evaluated against eight human pathogenic fungi. Compounds 1a, 1q, and 1r showed the more antifungal activity than the others. Dove Medical Press 2015-03-11 /pmc/articles/PMC4362653/ /pubmed/25792806 http://dx.doi.org/10.2147/DDDT.S74989 Text en © 2015 Xu et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Original Research
Xu, Kehan
Huang, Lei
Xu, Zheng
Wang, Yanwei
Bai, Guojing
Wu, Qiuye
Wang, Xiaoyan
Yu, Shichong
Jiang, Yuanying
Design, synthesis, and antifungal activities of novel triazole derivatives containing the benzyl group
title Design, synthesis, and antifungal activities of novel triazole derivatives containing the benzyl group
title_full Design, synthesis, and antifungal activities of novel triazole derivatives containing the benzyl group
title_fullStr Design, synthesis, and antifungal activities of novel triazole derivatives containing the benzyl group
title_full_unstemmed Design, synthesis, and antifungal activities of novel triazole derivatives containing the benzyl group
title_short Design, synthesis, and antifungal activities of novel triazole derivatives containing the benzyl group
title_sort design, synthesis, and antifungal activities of novel triazole derivatives containing the benzyl group
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4362653/
https://www.ncbi.nlm.nih.gov/pubmed/25792806
http://dx.doi.org/10.2147/DDDT.S74989
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