Inhibitor and Substrate Binding Induced Stability of HIV-1 Protease against Sequential Dissociation and Unfolding Revealed by High Pressure Spectroscopy and Kinetics

High-pressure methods have become an interesting tool of investigation of structural stability of proteins. They are used to study protein unfolding, but dissociation of oligomeric proteins can be addressed this way, too. HIV-1 protease, although an interesting object of biophysical experiments, has...

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Detalles Bibliográficos
Autores principales: Ingr, Marek, Lange, Reinhard, Halabalová, Věra, Yehya, Alaa, Hrnčiřík, Josef, Chevalier-Lucia, Dominique, Palmade, Laetitia, Blayo, Claire, Konvalinka, Jan, Dumay, Eliane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4362767/
https://www.ncbi.nlm.nih.gov/pubmed/25781460
http://dx.doi.org/10.1371/journal.pone.0119099

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4362767/
https://www.ncbi.nlm.nih.gov/pubmed/25781460
http://dx.doi.org/10.1371/journal.pone.0119099

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