STAT3 acts through pre-existing nucleosome-depleted regions bound by FOS during an epigenetic switch linking inflammation to cancer

BACKGROUND: Transient induction of the Src oncoprotein in a non-transformed breast cell line can initiate an epigenetic switch to a cancer cell via a positive feedback loop that involves activation of the signal transducer and activator of transcription 3 protein (STAT3) and NF-κB transcription fact...

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Detalles Bibliográficos
Autores principales: Fleming, Joseph D, Giresi, Paul G, Lindahl-Allen, Marianne, Krall, Elsa B, Lieb, Jason D, Struhl, Kevin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4362815/
https://www.ncbi.nlm.nih.gov/pubmed/25784959
http://dx.doi.org/10.1186/1756-8935-8-7

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