Blood–brain barrier dysfunction developed during normal aging is associated with inflammation and loss of tight junctions but not with leukocyte recruitment

BACKGROUND: Functional loss of blood–brain barrier (BBB) is suggested to be pivotal to pathogenesis and pathology of vascular-based neurodegenerative disorders such as Alzheimer’s disease. We recently reported in wild-type mice maintained on standard diets, progressive deterioration of capillary fun...

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Detalles Bibliográficos
Autores principales: Elahy, Mina, Jackaman, Connie, Mamo, John CL, Lam, Virginie, Dhaliwal, Satvinder S, Giles, Corey, Nelson, Delia, Takechi, Ryusuke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4362825/
https://www.ncbi.nlm.nih.gov/pubmed/25784952
http://dx.doi.org/10.1186/s12979-015-0029-9

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