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Two year effects of food allergen immunotherapy on quality of life in caregivers of children with food allergies

BACKGROUND: Food allergy (FA) can have serious psychosocial and economic repercussions on food-allergic children and their caregivers and be associated with negative effects on their quality of life. Food allergen immunotherapy (IT) is a promising experimental therapy but can be linked to anxiety. T...

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Autores principales: Arasi, Stefania, Otani, Iris M, Klingbeil, Erik, Bégin, Philippe, Kearney, Clare, Dominguez, Tina LR, Block, Whitney M, O’Riordan, Geraldine, Nadeau, Kari C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4363059/
https://www.ncbi.nlm.nih.gov/pubmed/25788951
http://dx.doi.org/10.1186/1710-1492-10-57
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author Arasi, Stefania
Otani, Iris M
Klingbeil, Erik
Bégin, Philippe
Kearney, Clare
Dominguez, Tina LR
Block, Whitney M
O’Riordan, Geraldine
Nadeau, Kari C
author_facet Arasi, Stefania
Otani, Iris M
Klingbeil, Erik
Bégin, Philippe
Kearney, Clare
Dominguez, Tina LR
Block, Whitney M
O’Riordan, Geraldine
Nadeau, Kari C
author_sort Arasi, Stefania
collection PubMed
description BACKGROUND: Food allergy (FA) can have serious psychosocial and economic repercussions on food-allergic children and their caregivers and be associated with negative effects on their quality of life. Food allergen immunotherapy (IT) is a promising experimental therapy but can be linked to anxiety. This study investigated the effects of IT on FA-specific health-related quality of life (HRQL) over a 24 month-follow-up in caregivers of children with single and multiple food allergies. We hypothesized that characteristics such as age, asthma at baseline and respiratory allergic reactions during therapy were key characteristics that influenced HRQL scores. METHODS: A validated Food Allergy Quality of Life – Parental Burden Questionnaire (FAQL-PB) was used to assess HRQL. It was randomly distributed to and filled out by caregivers of 57 food-allergic children enrolled in clinical trials of IT. The same parent answered the FABQL-PB questionnaire at baseline and for 6-month, 12- month, 18- month, and 24-month time points on IT. RESULTS: Caregiver HRQL improved significantly (change < - 0.5, p <0.0001) at each follow-up time point compared to baseline. The percentages of caregivers with improvement in HRQL progressively increased (92% at 24 month-follow-up time point compared to baseline). HRQL improved more in caregivers of participants older than 10 years or desensitized to more than 4 food allergens than those who were not (p <0.0001). Caregivers of participants with pre-existing asthma or dose-related respiratory allergic reactions had less improvement in HRQL than those who did not (p <0.01). CONCLUSION: IT lead to improvement in caregiver HRQL. Certain characteristics were associated with greater improvements in caregiver HRQL. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/1710-1492-10-57) contains supplementary material, which is available to authorized users.
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spelling pubmed-43630592015-03-19 Two year effects of food allergen immunotherapy on quality of life in caregivers of children with food allergies Arasi, Stefania Otani, Iris M Klingbeil, Erik Bégin, Philippe Kearney, Clare Dominguez, Tina LR Block, Whitney M O’Riordan, Geraldine Nadeau, Kari C Allergy Asthma Clin Immunol Research BACKGROUND: Food allergy (FA) can have serious psychosocial and economic repercussions on food-allergic children and their caregivers and be associated with negative effects on their quality of life. Food allergen immunotherapy (IT) is a promising experimental therapy but can be linked to anxiety. This study investigated the effects of IT on FA-specific health-related quality of life (HRQL) over a 24 month-follow-up in caregivers of children with single and multiple food allergies. We hypothesized that characteristics such as age, asthma at baseline and respiratory allergic reactions during therapy were key characteristics that influenced HRQL scores. METHODS: A validated Food Allergy Quality of Life – Parental Burden Questionnaire (FAQL-PB) was used to assess HRQL. It was randomly distributed to and filled out by caregivers of 57 food-allergic children enrolled in clinical trials of IT. The same parent answered the FABQL-PB questionnaire at baseline and for 6-month, 12- month, 18- month, and 24-month time points on IT. RESULTS: Caregiver HRQL improved significantly (change < - 0.5, p <0.0001) at each follow-up time point compared to baseline. The percentages of caregivers with improvement in HRQL progressively increased (92% at 24 month-follow-up time point compared to baseline). HRQL improved more in caregivers of participants older than 10 years or desensitized to more than 4 food allergens than those who were not (p <0.0001). Caregivers of participants with pre-existing asthma or dose-related respiratory allergic reactions had less improvement in HRQL than those who did not (p <0.01). CONCLUSION: IT lead to improvement in caregiver HRQL. Certain characteristics were associated with greater improvements in caregiver HRQL. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/1710-1492-10-57) contains supplementary material, which is available to authorized users. BioMed Central 2014-11-25 /pmc/articles/PMC4363059/ /pubmed/25788951 http://dx.doi.org/10.1186/1710-1492-10-57 Text en © Arasi et al.; licensee BioMed Central Ltd. 2014 This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Arasi, Stefania
Otani, Iris M
Klingbeil, Erik
Bégin, Philippe
Kearney, Clare
Dominguez, Tina LR
Block, Whitney M
O’Riordan, Geraldine
Nadeau, Kari C
Two year effects of food allergen immunotherapy on quality of life in caregivers of children with food allergies
title Two year effects of food allergen immunotherapy on quality of life in caregivers of children with food allergies
title_full Two year effects of food allergen immunotherapy on quality of life in caregivers of children with food allergies
title_fullStr Two year effects of food allergen immunotherapy on quality of life in caregivers of children with food allergies
title_full_unstemmed Two year effects of food allergen immunotherapy on quality of life in caregivers of children with food allergies
title_short Two year effects of food allergen immunotherapy on quality of life in caregivers of children with food allergies
title_sort two year effects of food allergen immunotherapy on quality of life in caregivers of children with food allergies
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4363059/
https://www.ncbi.nlm.nih.gov/pubmed/25788951
http://dx.doi.org/10.1186/1710-1492-10-57
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